OBJECTIVE: The incidence of colorectal cancer throughout the Republic of Korea has been rising over the last 25 years. The change in incidence is supposed to be due to the westernized life style. We evaluated the anatomical distribution of colorectal cancer and the properties of synchronous adenomatous polyps in the Korean population which were known to be different from those in Western countries. MATERIALS AND METHODS: From January 1997 to December 2006, 896 cases of colorectal cancer were reviewed retrospectively. RESULTS: A total of 25.1% were proximally located cancer with a modest female predominance (odds ratio 1.5). Synchronous adenomatous lesions were accompanied in 31.9% of all colorectal cancer cases. In the distal colorectal cancer patients, 18.8% had proximally located synchronous adenomas. In those with proximal colon cancer, only 20.5% of patients had distally located adenomas. The likelihood of a proximal colon cancer without distal sentinel lesions was higher in females (odds ratio 3.0). CONCLUSION: There has been a steep rise in the incidence of colorectal cancer in Korea and distal colon cancer is more prevalent than in Western countries. However, as over 20% of proximal colon cancers can exist without distal colonic synchronous or sentinel lesions, a total colonoscopic examination should be considered first in surveillance.
OBJECTIVE: The incidence of colorectal cancer throughout the Republic of Korea has been rising over the last 25 years. The change in incidence is supposed to be due to the westernized life style. We evaluated the anatomical distribution of colorectal cancer and the properties of synchronous adenomatous polyps in the Korean population which were known to be different from those in Western countries. MATERIALS AND METHODS: From January 1997 to December 2006, 896 cases of colorectal cancer were reviewed retrospectively. RESULTS: A total of 25.1% were proximally located cancer with a modest female predominance (odds ratio 1.5). Synchronous adenomatous lesions were accompanied in 31.9% of all colorectal cancer cases. In the distal colorectal cancerpatients, 18.8% had proximally located synchronous adenomas. In those with proximal colon cancer, only 20.5% of patients had distally located adenomas. The likelihood of a proximal colon cancer without distal sentinel lesions was higher in females (odds ratio 3.0). CONCLUSION: There has been a steep rise in the incidence of colorectal cancer in Korea and distal colon cancer is more prevalent than in Western countries. However, as over 20% of proximal colon cancers can exist without distal colonic synchronous or sentinel lesions, a total colonoscopic examination should be considered first in surveillance.
Authors: Michael Levi; Gintang Prayogi; Farid Sastranagara; Edi Sudianto; Grace Widjajahakim; Winiarti Gani; Albert Mahanadi; Jocelyn Agnes; Bela Haifa Khairunisa; Ahmad R Utomo Journal: J Gastrointest Cancer Date: 2018-06
Authors: Megan C Hanna; Christina Go; Christine Roden; Robert T Jones; Panisa Pochanard; Ahmed Yasir Javed; Awais Javed; Chandrani Mondal; Emanuele Palescandolo; Paul Van Hummelen; Charles Hatton; Adam J Bass; Sung Min Chun; Deuk Chae Na; Tae-Im Kim; Se Jin Jang; Raymond U Osarogiagbon; William C Hahn; Matthew Meyerson; Levi A Garraway; Laura E MacConaill Journal: PLoS One Date: 2013-09-16 Impact factor: 3.240