BACKGROUND: Previous studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability. AIMS: To test whether an association between advanced paternal age at birth is found in offspring with high-functioning autistic-spectrum disorder (i.e. offspring without intellectual disability). METHOD: A case-control study was conducted in Japan. The participants consisted of individuals with full-scale IQ>or=70, with a DSM-IV autistic disorder or related diagnosis. Unrelated healthy volunteers were recruited as controls. Parental ages were divided into tertiles (i.e. three age classes). Odds ratios and 95% confidence intervals were estimated using logistic regression analyses, with an adjustment for age, gender and birth order. RESULTS: Eighty-four individuals with autistic-spectrum disorder but without intellectual disability and 208 healthy controls were enrolled. Increased paternal, but not maternal, age was associated with an elevated risk of high-functioning autistic-spectrum disorder. A one-level advance in paternal age class corresponded to a 1.8-fold increase in risk, after adjustment for covariates. CONCLUSIONS: Advanced paternal age is associated with an increased risk for high-functioning autistic-spectrum disorder.
BACKGROUND: Previous studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability. AIMS: To test whether an association between advanced paternal age at birth is found in offspring with high-functioning autistic-spectrum disorder (i.e. offspring without intellectual disability). METHOD: A case-control study was conducted in Japan. The participants consisted of individuals with full-scale IQ>or=70, with a DSM-IV autistic disorder or related diagnosis. Unrelated healthy volunteers were recruited as controls. Parental ages were divided into tertiles (i.e. three age classes). Odds ratios and 95% confidence intervals were estimated using logistic regression analyses, with an adjustment for age, gender and birth order. RESULTS: Eighty-four individuals with autistic-spectrum disorder but without intellectual disability and 208 healthy controls were enrolled. Increased paternal, but not maternal, age was associated with an elevated risk of high-functioning autistic-spectrum disorder. A one-level advance in paternal age class corresponded to a 1.8-fold increase in risk, after adjustment for covariates. CONCLUSIONS: Advanced paternal age is associated with an increased risk for high-functioning autistic-spectrum disorder.
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Authors: Helen Leonard; Emma Glasson; Natasha Nassar; Andrew Whitehouse; Ami Bebbington; Jenny Bourke; Peter Jacoby; Glenys Dixon; Eva Malacova; Carol Bower; Fiona Stanley Journal: PLoS One Date: 2011-03-30 Impact factor: 3.240
Authors: Claire J Foldi; Darryl W Eyles; Traute Flatscher-Bader; John J McGrath; Thomas H J Burne Journal: Front Behav Neurosci Date: 2011-06-23 Impact factor: 3.558