Literature DB >> 18824606

In vitro activity of the antifungal plant defensin RsAFP2 against Candida isolates and its in vivo efficacy in prophylactic murine models of candidiasis.

Patricia M Tavares1, Karin Thevissen, Bruno P A Cammue, Isabelle E J A François, Eliana Barreto-Bergter, Carlos P Taborda, Alexandre F Marques, Marcio L Rodrigues, Leonardo Nimrichter.   

Abstract

We show that RsAFP2, a plant defensin that interacts with fungal glucosylceramides, is active against Candida albicans, inhibits to a lesser extent other Candida species, and is nontoxic to mammalian cells. Moreover, glucosylceramide levels in Candida species correlate with RsAFP2 sensitivity. We found RsAFP2 prophylactically effective against murine candidiasis.

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Year:  2008        PMID： 18824606      PMCID： PMC2592890          DOI： 10.1128/AAC.00448-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

1.  Lectin-mediated cell adhesion to immobilized glycosphingolipids.

Authors:  B E Collins; L J Yang; R L Schnaar
Journal:  Methods Enzymol       Date:  2000       Impact factor: 1.600

Review 2.  Therapeutic potential of antifungal plant and insect defensins.

Authors:  Karin Thevissen; Hans-Henrik Kristensen; Bart P H J Thomma; Bruno P A Cammue; Isabelle E J A François
Journal:  Drug Discov Today       Date:  2007-09-04       Impact factor: 7.851

3.  Efficacy of the partricin derivative SPA-S-753 against systemic murine candidosis.

Authors:  K V Clemons; D A Stevens
Journal:  J Antimicrob Chemother       Date:  2001-02       Impact factor: 5.790

Review 4.  Invasive fungal infections: a review of epidemiology and management options.

Authors:  D A Enoch; H A Ludlam; N M Brown
Journal:  J Med Microbiol       Date:  2006-07       Impact factor: 2.472

5.  Human antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growth.

Authors:  M L Rodrigues; L R Travassos; K R Miranda; A J Franzen; S Rozental; W de Souza; C S Alviano; E Barreto-Bergter
Journal:  Infect Immun       Date:  2000-12       Impact factor: 3.441

6.  Presence of glucosylceramide in yeast and its relation to alkali tolerance of yeast.

Authors:  Katsuichi Saito; Naoya Takakuwa; Masao Ohnishi; Yuji Oda
Journal:  Appl Microbiol Biotechnol       Date:  2005-10-14       Impact factor: 4.813

7.  Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection.

Authors:  Marcio L Rodrigues; Li Shi; Eliana Barreto-Bergter; Leonardo Nimrichter; Sandra E Farias; Elaine G Rodrigues; Luiz R Travassos; Joshua D Nosanchuk
Journal:  Clin Vaccine Immunol       Date:  2007-08-22

8.  The antifungal activity of RsAFP2, a plant defensin from raphanus sativus, involves the induction of reactive oxygen species in Candida albicans.

Authors:  An M Aerts; Isabelle E J A François; Els M K Meert; Qiu-Tian Li; Bruno P A Cammue; Karin Thevissen
Journal:  J Mol Microbiol Biotechnol       Date:  2007

9.  Comparison of pathogenicity of various Candida albicans and C. stellatoidea strains.

Authors:  Yoshio Okawa; Masayoshi Miyauchi; Shinichi Takahashi; Hidemitsu Kobayashi
Journal:  Biol Pharm Bull       Date:  2007-10       Impact factor: 2.233

10.  Glucosylceramide synthase is essential for alfalfa defensin-mediated growth inhibition but not for pathogenicity of Fusarium graminearum.

Authors:  Vellaisamy Ramamoorthy; Edgar B Cahoon; Jia Li; Mercy Thokala; Robert E Minto; Dilip M Shah
Journal:  Mol Microbiol       Date:  2007-10-01       Impact factor: 3.501
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  30 in total

Review 1.  Lipid signalling in pathogenic fungi.

Authors:  Arpita Singh; Maurizio Del Poeta
Journal:  Cell Microbiol       Date:  2010-12-05       Impact factor: 3.715

2.  Design of improved synthetic antifungal peptides with targeted variations in charge, hydrophobicity and chirality based on a correlation study between biological activity and primary structure of plant defensin γ-cores.

Authors:  Estefany Braz Toledo; Douglas Ribeiro Lucas; Thatiana Lopes Biá Ventura Simão; Sanderson Dias Calixto; Elena Lassounskaia; Michele Frazão Muzitano; Filipe Zanirati Damica; Valdirene Moreira Gomes; André de Oliveira Carvalho
Journal:  Amino Acids       Date:  2021-01-23       Impact factor: 3.520

Review 3.  Properties and mechanisms of action of naturally occurring antifungal peptides.

Authors:  Nicole L van der Weerden; Mark R Bleackley; Marilyn A Anderson
Journal:  Cell Mol Life Sci       Date:  2013-02-05       Impact factor: 9.261

4.  The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans.

Authors:  Karin Thevissen; Patricia de Mello Tavares; Deming Xu; Jill Blankenship; Davy Vandenbosch; Jolanta Idkowiak-Baldys; Gilmer Govaert; Anna Bink; Sonia Rozental; Piet W J de Groot; Talya R Davis; Carol A Kumamoto; Gabriele Vargas; Leonardo Nimrichter; Tom Coenye; Aaron Mitchell; Terry Roemer; Yusuf A Hannun; Bruno P A Cammue
Journal:  Mol Microbiol       Date:  2012-03-05       Impact factor: 3.501

5.  Cm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae).

Authors:  Carlos López-Abarrategui; Christine McBeth; Santi M Mandal; Zhenyu J Sun; Gregory Heffron; Annia Alba-Menéndez; Ludovico Migliolo; Osvaldo Reyes-Acosta; Mónica García-Villarino; Diego O Nolasco; Rosana Falcão; Mariana D Cherobim; Simoni C Dias; Wolfgang Brandt; Ludger Wessjohann; Michael Starnbach; Octavio L Franco; Anselmo J Otero-González
Journal:  FASEB J       Date:  2015-04-28       Impact factor: 5.191

6.  Antifungal activity of plant defensin AFP1 in Brassica juncea involves the recognition of the methyl residue in glucosylceramide of target pathogen Candida albicans.

Authors:  Yoshifumi Oguro; Harutake Yamazaki; Masamichi Takagi; Hiroaki Takaku
Journal:  Curr Genet       Date:  2013-11-20       Impact factor: 3.886

7.  A Paracoccidioides brasiliensis glycan shares serologic and functional properties with cryptococcal glucuronoxylomannan.

Authors:  Priscila C Albuquerque; Radames J B Cordero; Fernanda L Fonseca; Roberta Peres da Silva; Caroline L Ramos; Kildare R Miranda; Arturo Casadevall; Rosana Puccia; Joshua D Nosanchuk; Leonardo Nimrichter; Allan J Guimaraes; Marcio L Rodrigues
Journal:  Fungal Genet Biol       Date:  2012-09-23       Impact factor: 3.495

8.  Identification and mechanism of action of the plant defensin NaD1 as a new member of the antifungal drug arsenal against Candida albicans.

Authors:  Brigitte M E Hayes; Mark R Bleackley; Jennifer L Wiltshire; Marilyn A Anderson; Ana Traven; Nicole L van der Weerden
Journal:  Antimicrob Agents Chemother       Date:  2013-05-20       Impact factor: 5.191

Review 9.  Sphingolipids as targets for treatment of fungal infections.

Authors:  Rodrigo Rollin-Pinheiro; Ashutosh Singh; Eliana Barreto-Bergter; Maurizio Del Poeta
Journal:  Future Med Chem       Date:  2016-08-09       Impact factor: 3.808

10.  The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast.

Authors:  Caroline Struyfs; Tanne L Cools; Kaat De Cremer; Belém Sampaio-Marques; Paula Ludovico; Brian M Wasko; Matt Kaeberlein; Bruno P A Cammue; Karin Thevissen
Journal:  Biochim Biophys Acta Biomembr       Date:  2020-03-05       Impact factor: 3.747
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