| Literature DB >> 18824197 |
Hui Xu1, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami.
Abstract
Indoleamine 2,3-dioxygenase (IDO) has been well defined as one of the important immunosuppressive properties for T(H)1 cell-mediated immune responses, but its function in T(H)2 dominant system is poorly understood. Recently, an appreciable number of publications suggest that the role of IDO in T(H)2 cell regulation may be different from that of T(H)1 immune responses. Here we review the evidence on the regulatory function of IDO and tryptophan metabolites in T(H)1/T(H)2 differentiation. We propose that IDO-kynurenine pathway can serve as a negative feedback loop for T(H)1 cells but it may play a distinct role in up-regulating T(H)2 dominant immune responses.Entities:
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Year: 2008 PMID： 18824197 PMCID： PMC2628165 DOI： 10.1016/j.imlet.2008.08.008
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685