AIM: The Gly482Ser missense mutation of the transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) has been involved in insulin function impairments, with conflicting results. The current study investigated the relationships of carrying this polymorphism with insulin resistance (IR) during a short-term weight-loss and the subsequent weight follow-up. METHODS: The Gly482Ser was genotyped in 180 Spanish volunteers [body mass index: 31.4+/-3.2kg/m(2); age: 35+/-5 years]. Specific phenotypical measurements were determined at baseline, following an 8-week low-calorie diet (LCD) as well as after 6-month and 1-year of follow-up. RESULTS: At baseline the Ser482Ser genotype was associated with higher HOMA-IR and insulin concentrations than the other genotypes (p<0.05), which was accompanied by an increased higher risk of IR (OR: 2.97; 95% CI: 1.24-7.15). After following the LCD, such increased risk of insulin insensitivity in Ser482Ser carriers was toned down (p>0.05). This outcome was sustained after 6-month and 1-year of follow-up (p>0.05). CONCLUSIONS: These data show an increased risk of IR in obese carrying the rs8192673 Ser482Ser genotype. This risk was markedly reduced by an energy-restricted diet, which was sustained 6 months and 1 year after the diet therapy. This observation allows identifying obese subjects who might personally profit most from an energy-restrictive treatment concerning insulin response and lead to more individualized prognostic and therapeutic decisions.
AIM: The Gly482Ser missense mutation of the transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) has been involved in insulin function impairments, with conflicting results. The current study investigated the relationships of carrying this polymorphism with insulin resistance (IR) during a short-term weight-loss and the subsequent weight follow-up. METHODS: The Gly482Ser was genotyped in 180 Spanish volunteers [body mass index: 31.4+/-3.2kg/m(2); age: 35+/-5 years]. Specific phenotypical measurements were determined at baseline, following an 8-week low-calorie diet (LCD) as well as after 6-month and 1-year of follow-up. RESULTS: At baseline the Ser482Ser genotype was associated with higher HOMA-IR and insulin concentrations than the other genotypes (p<0.05), which was accompanied by an increased higher risk of IR (OR: 2.97; 95% CI: 1.24-7.15). After following the LCD, such increased risk of insulin insensitivity in Ser482Ser carriers was toned down (p>0.05). This outcome was sustained after 6-month and 1-year of follow-up (p>0.05). CONCLUSIONS: These data show an increased risk of IR in obese carrying the rs8192673 Ser482Ser genotype. This risk was markedly reduced by an energy-restricted diet, which was sustained 6 months and 1 year after the diet therapy. This observation allows identifying obese subjects who might personally profit most from an energy-restrictive treatment concerning insulin response and lead to more individualized prognostic and therapeutic decisions.
Authors: Lone G Rasmussen; Hanne Winning; Francesco Savorani; Christian Ritz; Søren B Engelsen; Arne Astrup; Thomas M Larsen; Lars O Dragsted Journal: Genes Nutr Date: 2011-10-09 Impact factor: 5.523
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Authors: Tessa Schillemans; Vinicius Tragante; Buamina Maitusong; Bruna Gigante; Sharon Cresci; Federica Laguzzi; Max Vikström; Mark Richards; Anna Pilbrow; Vicky Cameron; Luisa Foco; Robert N Doughty; Pekka Kuukasjärvi; Hooman Allayee; Jaana A Hartiala; W H Wilson Tang; Leo-Pekka Lyytikäinen; Kjell Nikus; Jari O Laurikka; Sundararajan Srinivasan; Ify R Mordi; Stella Trompet; Adriaan Kraaijeveld; Jessica van Setten; Crystel M Gijsberts; Anke H Maitland-van der Zee; Christoph H Saely; Yan Gong; Julie A Johnson; Rhonda M Cooper-DeHoff; Carl J Pepine; Gavino Casu; Andreas Leiherer; Heinz Drexel; Benjamin D Horne; Sander W van der Laan; Nicola Marziliano; Stanley L Hazen; Juha Sinisalo; Mika Kähönen; Terho Lehtimäki; Chim C Lang; Ralph Burkhardt; Markus Scholz; J Wouter Jukema; Niclas Eriksson; Axel Åkerblom; Stefan James; Claes Held; Emil Hagström; John A Spertus; Ale Algra; Ulf de Faire; Agneta Åkesson; Folkert W Asselbergs; Riyaz S Patel; Karin Leander Journal: Front Physiol Date: 2022-06-23 Impact factor: 4.755
Authors: M Gielen; M S Westerterp-Plantenga; F G Bouwman; A M C P Joosen; R Vlietinck; C Derom; M P Zeegers; E C M Mariman; K R Westerterp Journal: Genes Nutr Date: 2014-07-05 Impact factor: 5.523