Literature DB >> 18820949

Re-creation of the genetic composition of a founder population.

William Klitz1, Martin Maiers, Loren Gragert.   

Abstract

Human ethnic groups are frequently comprised of two or more founder populations. One of these founding populations is often available for contemporary sampling. We describe a method for reconstructing the composition of a missing founder population using the highly informative haplotypes comprising the HLA system. An application of the method is demonstrated using bone marrow registry samples of African Americans. We use contemporary samples of African Americans and European Americans to derive haplotypes of the West African founder populations. This approach may also be useful for reconstructing ancestral haplotypes for regions elsewhere in the genome.

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Year:  2008        PMID： 18820949     DOI： 10.1007/s00439-008-0565-x

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  16 in total

1.  SNPSTRs: empirically derived, rapidly typed, autosomal haplotypes for inference of population history and mutational processes.

Authors:  Joanna L Mountain; Alec Knight; Matthew Jobin; Christopher Gignoux; Adam Miller; Alice A Lin; Peter A Underhill
Journal:  Genome Res       Date:  2002-11       Impact factor: 9.043

2.  Information on ancestry from genetic markers.

Authors:  Carrie Lynn Pfaff; Jill Barnholtz-Sloan; Jennifer K Wagner; Jeffrey C Long
Journal:  Genet Epidemiol       Date:  2004-05       Impact factor: 2.135

3.  Genetic link between Chaoshan and other Chinese Han populations: Evidence from HLA-A and HLA-B allele frequency distribution.

Authors:  Sheng-Ping Hu; Jian-An Luan; Biao Li; Jing-Xi Chen; Ke-Li Cai; Li-Qun Huang; Xiao-Yan Xu
Journal:  Am J Phys Anthropol       Date:  2007-01       Impact factor: 2.868

4.  Dissecting racial and ethnic differences.

Authors:  Neil Risch
Journal:  N Engl J Med       Date:  2006-01-26       Impact factor: 91.245

5.  Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of mainland China.

Authors:  Lingling Chen; Shengying Qin; Jing Xie; Jimin Tang; Lun Yang; Wen Shen; Xinzhi Zhao; Jing Du; Guang He; Guoyin Feng; Lin He; Qinghe Xing
Journal:  Pharmacogenomics       Date:  2008-06       Impact factor: 2.533

6.  High-resolution HLA alleles and haplotypes in the United States population.

Authors:  Martin Maiers; Loren Gragert; William Klitz
Journal:  Hum Immunol       Date:  2007-05-24       Impact factor: 2.850

7.  Inferring admixture proportions from molecular data.

Authors:  G Bertorelle; L Excoffier
Journal:  Mol Biol Evol       Date:  1998-10       Impact factor: 16.240

8.  Admixture mapping for hypertension loci with genome-scan markers.

Authors:  Xiaofeng Zhu; Amy Luke; Richard S Cooper; Tom Quertermous; Craig Hanis; Tom Mosley; C Charles Gu; Hua Tang; Dabeeru C Rao; Neil Risch; Alan Weder
Journal:  Nat Genet       Date:  2005-01-23       Impact factor: 38.330

9.  Methods for high-density admixture mapping of disease genes.

Authors:  Nick Patterson; Neil Hattangadi; Barton Lane; Kirk E Lohmueller; David A Hafler; Jorge R Oksenberg; Stephen L Hauser; Michael W Smith; Stephen J O'Brien; David Altshuler; Mark J Daly; David Reich
Journal:  Am J Hum Genet       Date:  2004-04-14       Impact factor: 11.025

10.  Geographic patterns of genome admixture in Latin American Mestizos.

Authors:  Sijia Wang; Nicolas Ray; Winston Rojas; Maria V Parra; Gabriel Bedoya; Carla Gallo; Giovanni Poletti; Guido Mazzotti; Kim Hill; Ana M Hurtado; Beatriz Camrena; Humberto Nicolini; William Klitz; Ramiro Barrantes; Julio A Molina; Nelson B Freimer; Maria Cátira Bortolini; Francisco M Salzano; Maria L Petzl-Erler; Luiza T Tsuneto; José E Dipierri; Emma L Alfaro; Graciela Bailliet; Nestor O Bianchi; Elena Llop; Francisco Rothhammer; Laurent Excoffier; Andrés Ruiz-Linares
Journal:  PLoS Genet       Date:  2008-03-21       Impact factor: 5.917
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