Literature DB >> 18820757

Scaffold diversity of natural products: inspiration for combinatorial library design.

Kristina Grabowski1, Karl-Heinz Baringhaus, Gisbert Schneider.   

Abstract

Natural products contain scaffold structures that can be systematically exploited for the design of combinatorial compound libraries with druglike properties. We review approaches for scaffold identification, and compare properties and pharmacophoric features of drugs and natural products. In particular, an application of the self-organizing map technique is presented for natural product-derived compound and library design.

Mesh：

Substances：

Year:  2008        PMID： 18820757     DOI： 10.1039/b715668p

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  38 in total

Review 1.  Virtual screening: an endless staircase?

Authors:  Gisbert Schneider
Journal:  Nat Rev Drug Discov       Date:  2010-04       Impact factor: 84.694

2.  Revealing the macromolecular targets of complex natural products.

Authors:  Daniel Reker; Anna M Perna; Tiago Rodrigues; Petra Schneider; Michael Reutlinger; Bettina Mönch; Andreas Koeberle; Christina Lamers; Matthias Gabler; Heinrich Steinmetz; Rolf Müller; Manfred Schubert-Zsilavecz; Oliver Werz; Gisbert Schneider
Journal:  Nat Chem       Date:  2014-11-02       Impact factor: 24.427

Review 3.  The re-emergence of natural products for drug discovery in the genomics era.

Authors:  Alan L Harvey; RuAngelie Edrada-Ebel; Ronald J Quinn
Journal:  Nat Rev Drug Discov       Date:  2015-01-23       Impact factor: 84.694

4.  Natural-product-derived fragments for fragment-based ligand discovery.

Authors:  Björn Over; Stefan Wetzel; Christian Grütter; Yasushi Nakai; Steffen Renner; Daniel Rauh; Herbert Waldmann
Journal:  Nat Chem       Date:  2012-12-02       Impact factor: 24.427

Review 5.  Counting on natural products for drug design.

Authors:  Tiago Rodrigues; Daniel Reker; Petra Schneider; Gisbert Schneider
Journal:  Nat Chem       Date:  2016-04-25       Impact factor: 24.427

6.  Oxygen-containing fragments in natural products.

Authors:  Zoya Titarenko; Natalya Vasilevich; Vladimir Zernov; Michael Kirpichenok; Dmitry Genis
Journal:  J Comput Aided Mol Des       Date:  2012-12-28       Impact factor: 3.686

7.  Chemoselective enrichment for natural products discovery.

Authors:  Antoinette Y Odendaal; Darci J Trader; Erin E Carlson
Journal:  Chem Sci       Date:  2011-01-28       Impact factor: 9.825

Review 8.  Modern natural products drug discovery and its relevance to biodiversity conservation.

Authors:  David G I Kingston
Journal:  J Nat Prod       Date:  2010-12-07       Impact factor: 4.050

9.  Rapid and efficient access to secondary arylmethylamines.

Authors:  Nicolas Fleury-Brégeot; Jessica Raushel; Deidre L Sandrock; Spencer D Dreher; Gary A Molander
Journal:  Chemistry       Date:  2012-07-05       Impact factor: 5.236

10.  Skeletal diversity via cationic rearrangements of substituted dihydropyrans.

Authors:  Matthew R Medeiros; Radha S Narayan; Nolan T McDougal; Scott E Schaus; John A Porco
Journal:  Org Lett       Date:  2010-07-16       Impact factor: 6.005
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.