BACKGROUND: Fish contain n-3 polyunsaturated fatty acids, principally eicosapentaenoic acid and docosahexaenoic acid, which are known to interfere with the body's inflammatory response and may be of benefit in chronic inflammatory conditions. METHODS: We studied the relation between the dietary intake of n-3 fatty acids and chronic obstructive pulmonary disease (COPD) in 8960 current or former smokers participating in a population-based study of artheroscierosis. Intake of fatty acids was estimated with a dietary questionnaire. The presence of COPD was assessed by a questionnaire on respiratory symptoms and by spirometry. Three case definitions of COPD were used: symptoms of chronic bronchitis (667 subjects), physician-diagnosed emphysema reported by the subject (185 subjects), and spirometrically detected COPD (197 subjects). RESULTS: After control for pack-years of smoking, age, sex, race, height, weight, energy intake, and educational level docosahexaenoic acid was inversely related to the ris of COPD in a quantity-dependent fashion. The adjusted odds ratio for the highest quartile was 0.66 for chronic bronchitis (95 percent confidence interval, 0.52 to 0.85; P<0.001 for linear trend across the range of intake value), 0.31 for physician-diagnosed emphysema (95 percent confidence interval, 0.18 to 0.52; P for liner trend, 0.003), and 0.50 for spirometrically detected COPD (95 percent confidence interval, 0.32 to 0.79; P for linear trend, 0.007). CONCLUSION: A high dietary intake of n-3 fatty acids may protect cigarette smokers against COPD.
BACKGROUND: Fish contain n-3 polyunsaturated fatty acids, principally eicosapentaenoic acid and docosahexaenoic acid, which are known to interfere with the body's inflammatory response and may be of benefit in chronic inflammatory conditions. METHODS: We studied the relation between the dietary intake of n-3 fatty acids and chronic obstructive pulmonary disease (COPD) in 8960 current or former smokers participating in a population-based study of artheroscierosis. Intake of fatty acids was estimated with a dietary questionnaire. The presence of COPD was assessed by a questionnaire on respiratory symptoms and by spirometry. Three case definitions of COPD were used: symptoms of chronic bronchitis (667 subjects), physician-diagnosed emphysema reported by the subject (185 subjects), and spirometrically detected COPD (197 subjects). RESULTS: After control for pack-years of smoking, age, sex, race, height, weight, energy intake, and educational level docosahexaenoic acid was inversely related to the ris of COPD in a quantity-dependent fashion. The adjusted odds ratio for the highest quartile was 0.66 for chronic bronchitis (95 percent confidence interval, 0.52 to 0.85; P<0.001 for linear trend across the range of intake value), 0.31 for physician-diagnosed emphysema (95 percent confidence interval, 0.18 to 0.52; P for liner trend, 0.003), and 0.50 for spirometrically detected COPD (95 percent confidence interval, 0.32 to 0.79; P for linear trend, 0.007). CONCLUSION: A high dietary intake of n-3 fatty acids may protect cigarette smokers against COPD.
Authors: Rhea Powell; Duncan Davidson; Jasmin Divers; Ani Manichaikul; J Jeffrey Carr; Robert Detrano; Eric A Hoffman; Rui Jiang; Richard A Kronmal; Kiang Liu; Naresh M Punjabi; Eyal Shahar; Karol E Watson; Jerome I Rotter; Kent D Taylor; Stephen S Rich; R Graham Barr Journal: Thorax Date: 2013-04-12 Impact factor: 9.139
Authors: Mar Sorlí-Aguilar; Francisco Martín-Luján; Antoni Santigosa-Ayala; Josep Lluís Piñol-Moreso; Gemma Flores-Mateo; Josep Basora-Gallisà; Victoria Arija-Val; Rosa Solà-Alberich Journal: BMC Public Health Date: 2015-01-31 Impact factor: 3.295
Authors: Mar Sorli-Aguilar; Francisco Martin-Lujan; Gemma Flores-Mateo; Victoria Arija-Val; Josep Basora-Gallisa; Rosa Sola-Alberich Journal: BMC Pulm Med Date: 2016-11-25 Impact factor: 3.317