Literature DB >> 18818372

Review of the activation of TGF-beta in immunity.

Andrew W Taylor1.   

Abstract

The evolutionarily conserved TGF-beta proteins are distributed ubiquitously throughout the body and have a role in almost every biological process. In immunity, TGF-beta has an important role in modulating immunity. Much is understood about the process of TGF-beta production as a latent molecule and of the consequences and the intercellular signaling of active TGF-beta binding to its receptors; however, there is little discussed between the production and activation of TGF-beta. This review focuses on what is understood about the biochemical and physiological processes of TGF-beta activation and identifies the gaps in understanding immune cell activation of TGF-beta. A mechanistic understanding of the process activating TGF-beta can lead to regulating multiple biological systems by enhancing or inhibiting TGF-beta activation.

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Year:  2008        PMID： 18818372      PMCID： PMC3188956          DOI： 10.1189/jlb.0708415

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  65 in total

1.  The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

Authors:  M Kretzschmar; F Liu; A Hata; J Doody; J Massagué
Journal:  Genes Dev       Date:  1997-04-15       Impact factor: 11.361

Review 2.  Expression cloning of TGF-beta receptors.

Authors:  H Y Lin; X F Wang
Journal:  Mol Reprod Dev       Date:  1992-06       Impact factor: 2.609

3.  MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling.

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Journal:  Cell       Date:  1996-12-27       Impact factor: 41.582

Review 4.  TGF-beta latency: biological significance and mechanisms of activation.

Authors:  P E Gleizes; J S Munger; I Nunes; J G Harpel; R Mazzieri; I Noguera; D B Rifkin
Journal:  Stem Cells       Date:  1997       Impact factor: 6.277

5.  Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.

Authors:  H Yamashita; H Ichijo; S Grimsby; A Morén; P ten Dijke; K Miyazono
Journal:  J Biol Chem       Date:  1994-01-21       Impact factor: 5.157

6.  Processing of transforming growth factor beta 1 precursor by human furin convertase.

Authors:  C M Dubois; M H Laprise; F Blanchette; L E Gentry; R Leduc
Journal:  J Biol Chem       Date:  1995-05-05       Impact factor: 5.157

7.  Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Authors:  A B Kulkarni; C G Huh; D Becker; A Geiser; M Lyght; K C Flanders; A B Roberts; M B Sporn; J M Ward; S Karlsson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

8.  Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

Authors:  X Z Huang; J F Wu; D Cass; D J Erle; D Corry; S G Young; R V Farese; D Sheppard
Journal:  J Cell Biol       Date:  1996-05       Impact factor: 10.539

9.  The mechanism for the activation of latent TGF-beta during co-culture of endothelial cells and smooth muscle cells: cell-type specific targeting of latent TGF-beta to smooth muscle cells.

Authors:  Y Sato; F Okada; M Abe; T Seguchi; M Kuwano; S Sato; A Furuya; N Hanai; T Tamaoki
Journal:  J Cell Biol       Date:  1993-12       Impact factor: 10.539

10.  Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein.

Authors:  J Taipale; K Miyazono; C H Heldin; J Keski-Oja
Journal:  J Cell Biol       Date:  1994-01       Impact factor: 10.539
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  63 in total

1.  Primary Open-Angle Glaucoma: A Transforming Growth Factor-β Pathway-Mediated Disease.

Authors:  Andrew W Taylor
Journal:  Am J Pathol       Date:  2012-04-21       Impact factor: 4.307

Review 2.  Innate immunity in vertebrates: an overview.

Authors:  Mario Riera Romo; Dayana Pérez-Martínez; Camila Castillo Ferrer
Journal:  Immunology       Date:  2016-04-05       Impact factor: 7.397

3.  Kinase activity profiling of gram-negative pneumonia.

Authors:  Arie J Hoogendijk; Sander H Diks; Maikel P Peppelenbosch; Tom Van Der Poll; Catharina W Wieland
Journal:  Mol Med       Date:  2011-03-15       Impact factor: 6.354

4.  Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation.

Authors:  L Faustino; D M Fonseca; E B Florsheim; R R Resende; A P Lepique; E Faquim-Mauro; E Gomes; J S Silva; H Yagita; M Russo
Journal:  Mucosal Immunol       Date:  2014-02-26       Impact factor: 7.313

5.  Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells.

Authors:  Monica Bodogai; Kanako Moritoh; Catalina Lee-Chang; Christine M Hollander; Cheryl A Sherman-Baust; Robert P Wersto; Yoshihiko Araki; Ichiro Miyoshi; Li Yang; Giorgio Trinchieri; Arya Biragyn
Journal:  Cancer Res       Date:  2015-07-16       Impact factor: 12.701

6.  Variation in inflammatory/regulatory cytokines in secondary, tertiary, and quaternary challenges with dengue virus.

Authors:  Beatriz Sierra; Ana B Pérez; Mayling Alvarez; Gissel García; Katrin Vogt; Eglys Aguirre; Kathrin Schmolke; Hans-Dieter Volk; María G Guzmán
Journal:  Am J Trop Med Hyg       Date:  2012-07-16       Impact factor: 2.345

7.  The parallel lives of angiogenesis and immunosuppression: cancer and other tales.

Authors:  Gregory T Motz; George Coukos
Journal:  Nat Rev Immunol       Date:  2011-09-23       Impact factor: 53.106

8.  RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors.

Authors:  Zhenqiang Yao; Wei Lei; Rong Duan; Yanyun Li; Lu Luo; Brendan F Boyce
Journal:  J Biol Chem       Date:  2017-04-24       Impact factor: 5.157

9.  Regulation of genes affecting body size and innate immunity by the DBL-1/BMP-like pathway in Caenorhabditis elegans.

Authors:  Andrew F Roberts; Tina L Gumienny; Ryan J Gleason; Huang Wang; Richard W Padgett
Journal:  BMC Dev Biol       Date:  2010-06-07       Impact factor: 1.978

10.  Differential transcript expression between the microfilariae of the filarial nematodes, Brugia malayi and B. pahangi.

Authors:  Michael M Kariuki; Leonard B Hearne; Brenda T Beerntsen
Journal:  BMC Genomics       Date:  2010-04-07       Impact factor: 3.969
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