Literature DB >> 18818074

Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA.

Rob C Oslund1, Nathan Cermak, Christophe L M J Verlinde, Michael H Gelb.   

Abstract

Simplified analogs of YM-26734, a known inhibitor of secreted phospholipase A(2) (sPLA(2)) group IIA, were synthesized and found to also display potent inhibition at low nanomolar concentrations. Analogs were based on the didodecanoylphloroglucinol portion of YM-26734 which contains the predicted active site calcium binding group.

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Year:  2008        PMID： 18818074      PMCID： PMC2578825          DOI： 10.1016/j.bmcl.2008.09.041

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

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