BACKGROUND AND OBJECTIVES: Hyperphosphatemia is an independent risk factor for mortality in ESRD, but factors regulating phosphate clearance on peritoneal dialysis (PD) are incompletely understood. The objective of this study was to test the hypothesis that peritoneal phosphate clearance is better with continuous ambulatory PD (CAPD) as compared with continuous cyclic PD (CCPD) after adjusting for membrane transport status. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this cross-sectional and retrospective study, measurements of peritoneal phosphate clearance of 129 prevalent PD patients were reviewed. Patients were divided according to membrane transport status (high, high average, low average-low categories) and PD modality (CAPD or CCPD). RESULTS: Among high transporters, peritoneal phosphate clearances were comparable in both modalities. However, treatment with CAPD was associated with increased peritoneal phosphate clearance compared with CCPD among high-average transporters (42.4 +/- 11.4 versus 36.4 +/- 8.3 L/wk/1.73 m(2), P = 0.01), and low-average-low transporters (35.6 +/- 5.9 versus 28.9 +/- 11 L/wk/1.73 m(2), P = 0.034). On multivariate linear regression, PD modality, membrane transport category, and peritoneal creatinine clearance, but not Kt/V urea, were independently associated with peritoneal phosphate clearance. CONCLUSIONS: Peritoneal phosphate clearance is determined by PD modality and membrane transport category, suggesting that PD regimes with longer dwell times may help control hyperphosphatemia in lower transporters.
BACKGROUND AND OBJECTIVES:Hyperphosphatemia is an independent risk factor for mortality in ESRD, but factors regulating phosphate clearance on peritoneal dialysis (PD) are incompletely understood. The objective of this study was to test the hypothesis that peritoneal phosphate clearance is better with continuous ambulatory PD (CAPD) as compared with continuous cyclic PD (CCPD) after adjusting for membrane transport status. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this cross-sectional and retrospective study, measurements of peritoneal phosphate clearance of 129 prevalent PDpatients were reviewed. Patients were divided according to membrane transport status (high, high average, low average-low categories) and PD modality (CAPD or CCPD). RESULTS: Among high transporters, peritoneal phosphate clearances were comparable in both modalities. However, treatment with CAPD was associated with increased peritoneal phosphate clearance compared with CCPD among high-average transporters (42.4 +/- 11.4 versus 36.4 +/- 8.3 L/wk/1.73 m(2), P = 0.01), and low-average-low transporters (35.6 +/- 5.9 versus 28.9 +/- 11 L/wk/1.73 m(2), P = 0.034). On multivariate linear regression, PD modality, membrane transport category, and peritoneal creatinine clearance, but not Kt/V urea, were independently associated with peritoneal phosphate clearance. CONCLUSIONS: Peritoneal phosphate clearance is determined by PD modality and membrane transport category, suggesting that PD regimes with longer dwell times may help control hyperphosphatemia in lower transporters.
Authors: Wai-Kei Lo; Joanne M Bargman; John Burkart; Raymond T Krediet; Carol Pollock; Hideki Kawanishi; Peter G Blake Journal: Perit Dial Int Date: 2006 Sep-Oct Impact factor: 1.756
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Authors: P Gallar; O Ortega; M Gutiérrez; M Muñoz; L Hilara; A Oliet; I Rodríguez; E Giménez; A Vigil Journal: Nefrologia Date: 2000 Jul-Aug Impact factor: 2.033
Authors: Ana Paula Bernardo; Sebastián Azorin Contesse; Maria Auxiliadora Bajo; Anabela Rodrigues; Gloria Del Peso; Marta Ossorio; António Cabrita; Rafael Selgas Journal: Clin J Am Soc Nephrol Date: 2010-11-29 Impact factor: 8.237
Authors: Rachel M Holden; Reem A Mustafa; R Todd Alexander; Marisa Battistella; Micheli U Bevilacqua; Greg Knoll; Fabrice Mac-Way; Martina Reslerova; Ron Wald; Philip D Acott; Patrick Feltmate; Allan Grill; Kailash K Jindal; Meena Karsanji; Bryce A Kiberd; Sara Mahdavi; Kailee McCarron; Amber O Molnar; Maury Pinsk; Celia Rodd; Steven D Soroka; Amanda J Vinson; Deborah Zimmerman; Catherine M Clase Journal: Can J Kidney Health Dis Date: 2020-08-04