Literature DB >> 18812184

Ratio of lethal and edema factors in rabbit systemic anthrax.

Federica Dal Molin1, Antonio Fasanella, Morena Simonato, Giuliano Garofolo, Cesare Montecucco, Fiorella Tonello.   

Abstract

Bacillus anthracis secretes two binary toxins: lethal toxin (PA + LF) and edema toxin (PA + EF) that play a major role in the pathogenesis of anthrax. Their activities can synergize or interfere among each other, depending on the cell type. It is therefore fundamental to know their concentration ratio in vivo. Here, we report the first determination of the concentration ratio of anthrax toxin components LF/EF in the serum of rabbits infected with B. anthracis spores.

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Year:  2008        PMID： 18812184     DOI： 10.1016/j.toxicon.2008.08.011

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  28 in total

Review 1.  Anthrax lethal and edema toxins in anthrax pathogenesis.

Authors:  Shihui Liu; Mahtab Moayeri; Stephen H Leppla
Journal:  Trends Microbiol       Date:  2014-03-27       Impact factor: 17.079

2.  Key tissue targets responsible for anthrax-toxin-induced lethality.

Authors:  Shihui Liu; Yi Zhang; Mahtab Moayeri; Jie Liu; Devorah Crown; Rasem J Fattah; Alexander N Wein; Zu-Xi Yu; Toren Finkel; Stephen H Leppla
Journal:  Nature       Date:  2013-08-28       Impact factor: 49.962

Review 3.  Targeting Metalloenzymes for Therapeutic Intervention.

Authors:  Allie Y Chen; Rebecca N Adamek; Benjamin L Dick; Cy V Credille; Christine N Morrison; Seth M Cohen
Journal:  Chem Rev       Date:  2018-09-07       Impact factor: 60.622

4.  Bacillus anthracis lethal toxin, but not edema toxin, increases pulmonary artery pressure and permeability in isolated perfused rat lungs.

Authors:  Xizhong Cui; Wanying Xu; Pranita Neupane; Andie Weiser-Schlesinger; Ray Weng; Benjamin Pockros; Yan Li; Mahtab Moayeri; Stephen H Leppla; Yvonne Fitz; Peter Q Eichacker
Journal:  Am J Physiol Heart Circ Physiol       Date:  2019-02-15       Impact factor: 4.733

Review 5.  Designing inhibitors of anthrax toxin.

Authors:  Ekaterina M Nestorovich; Sergey M Bezrukov
Journal:  Expert Opin Drug Discov       Date:  2014-01-22       Impact factor: 6.098

6.  Accurate and selective quantification of anthrax protective antigen in plasma by immunocapture and isotope dilution mass spectrometry.

Authors:  Maria I Solano; Adrian R Woolfitt; Anne E Boyer; Renato C Lins; Katie Isbell; Maribel Gallegos-Candela; Hercules Moura; Carrie L Pierce; John R Barr
Journal:  Analyst       Date:  2019-03-25       Impact factor: 4.616

7.  Bacillus anthracis Edema Toxin Increases Fractional Free Water and Sodium Reabsorption in an Isolated Perfused Rat Kidney Model.

Authors:  Dharmvir S Jaswal; Xizhong Cui; Parizad Torabi-Parizi; Lernik Ohanjanian; Hannish Sampath-Kumar; Yvonne Fitz; Yan Li; Wanying Xu; Peter Q Eichacker
Journal:  Infect Immun       Date:  2017-06-20       Impact factor: 3.441

8.  Anthrax lethal toxin enhances IkappaB kinase activation and differentially regulates pro-inflammatory genes in human endothelium.

Authors:  Jason M Warfel; Felice D'Agnillo
Journal:  J Biol Chem       Date:  2009-07-20       Impact factor: 5.157

9.  Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo.

Authors:  Shihui Liu; Devorah Crown; Sharmina Miller-Randolph; Mahtab Moayeri; Hailun Wang; Haijing Hu; Thomas Morley; Stephen H Leppla
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-15       Impact factor: 11.205

Review 10.  Cellular and systemic effects of anthrax lethal toxin and edema toxin.

Authors:  Mahtab Moayeri; Stephen H Leppla
Journal:  Mol Aspects Med       Date:  2009-07-26
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