PURPOSE: To present a new approach for evaluating intraocular lenses (IOLs) for retinal protection from age-related lipofuscin accumulation-mediated phototoxicity. SETTING: Alcon Laboratories Inc., Fort Worth, Texas, USA, and Cardiff University, Cardiff, United Kingdom. METHODS: Age-related lipofuscin accumulation-mediated action spectra for retinal phototoxicity in an aphakic eye were created for this evaluation. Transmission curves for 6 IOLs and for cornea and spectral radiant power distribution for sunlight and 2 lamps were used. Pseudophakic action spectra and retinal phototoxicity for 3 wavelength ranges and 3 ages were computed. The percentage protection of each IOL was computed as the reduction in phototoxicity relative to the aphakic eye. RESULTS: Retinal phototoxicity increased 3.66 times from the third to ninth decade of age. The comparative retinal phototoxicity and retinal protection provided by IOLs were dependent on the light source and range of wavelength; however, unlike phototoxicity, retinal protection was independent of age. The 420 to 480 nm range was the most useful for discriminating protection by IOLs. CONCLUSIONS: Retinal phototoxicity significantly increased with age; however, the retinal protection by IOLs was independent of age. The interaction between the transmission curve of IOLs and light sources required inclusion of widely used lamps besides sunlight for evaluation of IOLs. For the 420 to 480 nm wavelength range, the 3 light sources clearly discriminated the protection provided by IOLs. The AcrySof Natural IOL (Alcon) provided the highest protection consistently for the tested light sources.
PURPOSE: To present a new approach for evaluating intraocular lenses (IOLs) for retinal protection from age-related lipofuscin accumulation-mediated phototoxicity. SETTING: Alcon Laboratories Inc., Fort Worth, Texas, USA, and Cardiff University, Cardiff, United Kingdom. METHODS: Age-related lipofuscin accumulation-mediated action spectra for retinal phototoxicity in an aphakic eye were created for this evaluation. Transmission curves for 6 IOLs and for cornea and spectral radiant power distribution for sunlight and 2 lamps were used. Pseudophakic action spectra and retinal phototoxicity for 3 wavelength ranges and 3 ages were computed. The percentage protection of each IOL was computed as the reduction in phototoxicity relative to the aphakic eye. RESULTS: Retinal phototoxicity increased 3.66 times from the third to ninth decade of age. The comparative retinal phototoxicity and retinal protection provided by IOLs were dependent on the light source and range of wavelength; however, unlike phototoxicity, retinal protection was independent of age. The 420 to 480 nm range was the most useful for discriminating protection by IOLs. CONCLUSIONS: Retinal phototoxicity significantly increased with age; however, the retinal protection by IOLs was independent of age. The interaction between the transmission curve of IOLs and light sources required inclusion of widely used lamps besides sunlight for evaluation of IOLs. For the 420 to 480 nm wavelength range, the 3 light sources clearly discriminated the protection provided by IOLs. The AcrySof Natural IOL (Alcon) provided the highest protection consistently for the tested light sources.
Authors: Emma C Zanzottera; Thomas Ach; Carrie Huisingh; Jeffrey D Messinger; Richard F Spaide; Christine A Curcio Journal: Retina Date: 2016-12 Impact factor: 4.256
Authors: Thomas Ach; Carrie Huisingh; Gerald McGwin; Jeffrey D Messinger; Tianjiao Zhang; Mark J Bentley; Danielle B Gutierrez; Zsolt Ablonczy; R Theodore Smith; Kenneth R Sloan; Christine A Curcio Journal: Invest Ophthalmol Vis Sci Date: 2014-07-17 Impact factor: 4.799
Authors: James A Davison; Anil S Patel; Joao P Cunha; Jim Schwiegerling; Orkun Muftuoglu Journal: Graefes Arch Clin Exp Ophthalmol Date: 2011-05-17 Impact factor: 3.117