OBJECTIVE: To determine whether the routine use of preimplantation genetic screening (PGS) in "good prognosis" women improves in vitro fertilization (IVF) cycle outcome. DESIGN: Randomized, controlled, prospective clinical study. SETTING:Private infertility clinic. PATIENT(S): Infertile women predicted to have a good prognosis as defined by: age <39 years, normal ovarian reserve, body mass index <30 kg/m(2), presence of ejaculated sperm, normal uterus, <or=2 previous failed IVF cycles. INTERVENTION(S): Patients were randomized to the PGS group or the control group on day 3 after oocyte retrieval; 23 women underwent blastomere biopsy on day 3 after fertilization (PGS group), and 24 women underwent routine IVF (control group). All embryos were transferred on day 5 or 6 after fertilization. MAIN OUTCOME MEASURE(S): Pregnancy, implantation, multiple gestation, and live birth rates. RESULT(S): No statistically significant differences were found between the PGS and control groups with respect to clinical pregnancy rate (52.4% versus 72.7%). However, the embryo implantation rate was statistically significantly lower for the PGS group (31.7% versus 62.3%) as were the live birth rate (28.6% versus 68.2%) and the multiple birth rate (9.1% versus 46.7%). CONCLUSION(S): In a "good prognosis" population of women, PGS does not appear to improve pregnancy, implantation, or live birth rates.
RCT Entities:
OBJECTIVE: To determine whether the routine use of preimplantation genetic screening (PGS) in "good prognosis" women improves in vitro fertilization (IVF) cycle outcome. DESIGN: Randomized, controlled, prospective clinical study. SETTING: Private infertility clinic. PATIENT(S): Infertile women predicted to have a good prognosis as defined by: age <39 years, normal ovarian reserve, body mass index <30 kg/m(2), presence of ejaculated sperm, normal uterus, <or=2 previous failed IVF cycles. INTERVENTION(S): Patients were randomized to the PGS group or the control group on day 3 after oocyte retrieval; 23 women underwent blastomere biopsy on day 3 after fertilization (PGS group), and 24 women underwent routine IVF (control group). All embryos were transferred on day 5 or 6 after fertilization. MAIN OUTCOME MEASURE(S): Pregnancy, implantation, multiple gestation, and live birth rates. RESULT(S): No statistically significant differences were found between the PGS and control groups with respect to clinical pregnancy rate (52.4% versus 72.7%). However, the embryo implantation rate was statistically significantly lower for the PGS group (31.7% versus 62.3%) as were the live birth rate (28.6% versus 68.2%) and the multiple birth rate (9.1% versus 46.7%). CONCLUSION(S): In a "good prognosis" population of women, PGS does not appear to improve pregnancy, implantation, or live birth rates.
Authors: Miguel A Checa; Pablo Alonso-Coello; Ivan Solà; Ana Robles; Ramón Carreras; Juan Balasch Journal: J Assist Reprod Genet Date: 2009-07-24 Impact factor: 3.412
Authors: Sandra Zamora; Ana Clavero; M Carmen Gonzalvo; Juan de Dios Luna Del Castillo; Jose Antonio Roldán-Nofuentes; Juan Mozas; Jose Antonio Castilla Journal: J Assist Reprod Genet Date: 2011-06-29 Impact factor: 3.412
Authors: Joep Geraedts; Markus Montag; M Cristina Magli; Sjoerd Repping; Alan Handyside; Catherine Staessen; Joyce Harper; Andreas Schmutzler; John Collins; Veerle Goossens; Hans van der Ven; Katerina Vesela; Luca Gianaroli Journal: Hum Reprod Date: 2011-09-09 Impact factor: 6.918
Authors: D S Johnson; G Gemelos; J Baner; A Ryan; C Cinnioglu; M Banjevic; R Ross; M Alper; B Barrett; J Frederick; D Potter; B Behr; M Rabinowitz Journal: Hum Reprod Date: 2010-01-24 Impact factor: 6.918