Literature DB >> 18803570

CaMKII and its role in cardiac arrhythmia.

Jeffrey R Erickson1, Mark E Anderson.   

Abstract

Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase widely distributed in a number of tissue types. Activation of CaMKII has been linked to important downstream physiological processes, including apoptosis, hypertrophy, and arrhythmia in the heart. Pharmacological or genetic inhibition of CaMKII has been shown to improve health outcomes in a number of animal models. In this review, we summarize the structural and functional properties of CaMKII and detail its role in cardiac arrhythmia, structural heart disease, and sudden death.

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Year:  2008        PMID： 18803570     DOI： 10.1111/j.1540-8167.2008.01295.x

Source DB:  PubMed          Journal:  J Cardiovasc Electrophysiol        ISSN： 1045-3873


  16 in total

1.  S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II δ.

Authors:  Jeffrey R Erickson; C Blake Nichols; Hitoshi Uchinoumi; Matthew L Stein; Julie Bossuyt; Donald M Bers
Journal:  J Biol Chem       Date:  2015-08-27       Impact factor: 5.157

2.  Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias.

Authors:  M Said; R Becerra; C A Valverde; M A Kaetzel; J R Dedman; C Mundiña-Weilenmann; X H Wehrens; L Vittone; A Mattiazzi
Journal:  J Mol Cell Cardiol       Date:  2011-08-19       Impact factor: 5.000

Review 3.  Na+ channel function, regulation, structure, trafficking and sequestration.

Authors:  Ye Chen-Izu; Robin M Shaw; Geoffrey S Pitt; Vladimir Yarov-Yarovoy; Jon T Sack; Hugues Abriel; Richard W Aldrich; Luiz Belardinelli; Mark B Cannell; William A Catterall; Walter J Chazin; Nipavan Chiamvimonvat; Isabelle Deschenes; Eleonora Grandi; Thomas J Hund; Leighton T Izu; Lars S Maier; Victor A Maltsev; Celine Marionneau; Peter J Mohler; Sridharan Rajamani; Randall L Rasmusson; Eric A Sobie; Colleen E Clancy; Donald M Bers
Journal:  J Physiol       Date:  2015-03-15       Impact factor: 5.182

4.  Stretch current-induced abnormal impulses in CaMKIIδ knockout mouse ventricular myocytes.

Authors:  Dongwu Lai; Lin Xu; Jun Cheng; Arnaud B Guilbert; Hyun Joung Lim; Guosheng Fu; Yanggan Wang
Journal:  J Cardiovasc Electrophysiol       Date:  2012-12-21

5.  Cardiac Na Channels: Structure to Function.

Authors:  K R DeMarco; C E Clancy
Journal:  Curr Top Membr       Date:  2016-06-14       Impact factor: 3.049

Review 6.  Targeting ryanodine receptors for anti-arrhythmic therapy.

Authors:  Mark D McCauley; Xander H T Wehrens
Journal:  Acta Pharmacol Sin       Date:  2011-06       Impact factor: 6.150

Review 7.  Cardiac calmodulin kinase: a potential target for drug design.

Authors:  T Bányász; N Szentandrássy; A Tóth; P P Nánási; J Magyar; Y Chen-Izu
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

Review 8.  Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias.

Authors:  Paari Dominic Swaminathan; Anil Purohit; Thomas J Hund; Mark E Anderson
Journal:  Circ Res       Date:  2012-06-08       Impact factor: 17.367

9.  CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes.

Authors:  Scott M MacDonnell; Jutta Weisser-Thomas; Hajime Kubo; Marie Hanscome; Qinghang Liu; Naser Jaleel; Remus Berretta; Xiongwen Chen; Joan H Brown; Abdel-Karim Sabri; Jeffery D Molkentin; Steven R Houser
Journal:  Circ Res       Date:  2009-07-16       Impact factor: 17.367

10.  CaMKII-dependent late Na+ current increases electrical dispersion and arrhythmia in ischemia-reperfusion.

Authors:  Taylor Howard; Amara Greer-Short; Tony Satroplus; Nehal Patel; Drew Nassal; Peter J Mohler; Thomas J Hund
Journal:  Am J Physiol Heart Circ Physiol       Date:  2018-06-22       Impact factor: 4.733
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