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Literature DB >> 18802628

Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I.

Tatiana Y Zakharian¹, Luigi Di Costanzo, David W Christianson.

Abstract

The synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid is reported along with the X-ray crystal structure of its complex with human arginase I, revealing unique coordination interactions with two manganese ions in the enzyme active site.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18802628 PMCID： PMC2790808 DOI： 10.1039/b811797g

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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