| Literature DB >> 10866372 |
J Tilley1, G Kaplan, N Fotouhi, B Wolitzky, K Rowan.
Abstract
Substitution of carbon for sulfur in a potent 13-membered cyclic disulfide containing peptide was accomplished via an intramolecular Wittig reaction and resulted in a series of 'carba' analogues. Potency in the VCAM-VLA-4 assay was sensitive to ring size and lower than that of the parent disulfide.Entities:
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Year: 2000 PMID： 10866372 DOI： 10.1016/s0960-894x(00)00173-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823