Literature DB >> 19724793

Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA.

Linlin Zhao1, John B Schenkman, James F Rusling.   

Abstract

We demonstrate for the first time the combination of human liver cytosol and microsomal enzyme sources into an electro-optical array to screen for reactive metabolites produced in multi-enzyme metabolic processes.

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Year:  2009        PMID: 19724793      PMCID: PMC3475954          DOI: 10.1039/b909372a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  23 in total

Review 1.  An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons.

Authors:  Esther F A Brandon; Christiaan D Raap; Irma Meijerman; Jos H Beijnen; Jan H M Schellens
Journal:  Toxicol Appl Pharmacol       Date:  2003-06-15       Impact factor: 4.219

2.  Electrochemical biosensor featuring a two-enzyme pathway and DNA for screening toxic reactive metabolites of arylamines.

Authors:  Minjeong So; John B Schenkman; James F Rusling
Journal:  Chem Commun (Camb)       Date:  2008-07-18       Impact factor: 6.222

Review 3.  Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents.

Authors:  A K Basu; J M Essigmann
Journal:  Chem Res Toxicol       Date:  1988 Jan-Feb       Impact factor: 3.739

Review 4.  Historical perspectives on conjugation-dependent bioactivation of foreign compounds.

Authors:  J A Miller; Y J Surh
Journal:  Adv Pharmacol       Date:  1994

5.  Simultaneous direct electrochemiluminescence and catalytic voltammetry detection of DNA in ultrathin films.

Authors:  Lynn Dennany; Robert J Forster; James F Rusling
Journal:  J Am Chem Soc       Date:  2003-04-30       Impact factor: 15.419

6.  Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.

Authors:  N Ozawa; F P Guengerich
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

7.  Application of capillary liquid chromatography coupled with tandem mass spectrometric methods to the rapid screening of adducts formed by the reaction of N-acetoxy-N-acetyl-2-aminofluorene with calf thymus DNA.

Authors:  S M Wolf; P Vouros
Journal:  Chem Res Toxicol       Date:  1994 Jan-Feb       Impact factor: 3.739

Review 8.  Activation of dihaloalkanes by thiol-dependent mechanisms.

Authors:  F Peter Guengerich
Journal:  J Biochem Mol Biol       Date:  2003-01-31

Review 9.  Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios.

Authors:  J Andrew Williams; Ruth Hyland; Barry C Jones; Dennis A Smith; Susan Hurst; Theunis C Goosen; Vincent Peterkin; Jeffrey R Koup; Simon E Ball
Journal:  Drug Metab Dispos       Date:  2004-08-10       Impact factor: 3.922

10.  Differences in metabolite-mediated toxicity of tamoxifen in rodents versus humans elucidated with DNA/microsome electro-optical arrays and nanoreactors.

Authors:  Linlin Zhao; Sadagopan Krishnan; Yun Zhang; John B Schenkman; James F Rusling
Journal:  Chem Res Toxicol       Date:  2009-02       Impact factor: 3.739

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  4 in total

1.  High-throughput metabolic toxicity screening using magnetic biocolloid reactors and LC-MS/MS.

Authors:  Linlin Zhao; John B Schenkman; James F Rusling
Journal:  Anal Chem       Date:  2010-11-19       Impact factor: 6.986

Review 2.  Metabolic toxicity screening using electrochemiluminescence arrays coupled with enzyme-DNA biocolloid reactors and liquid chromatography-mass spectrometry.

Authors:  Eli G Hvastkovs; John B Schenkman; James F Rusling
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2012-04-05       Impact factor: 10.745

3.  Evaluation of electrochemiluminescent metabolic toxicity screening arrays using a multiple compound set.

Authors:  Shenmin Pan; Linlin Zhao; John B Schenkman; James F Rusling
Journal:  Anal Chem       Date:  2011-03-11       Impact factor: 6.986

4.  Genotoxicity-related chemistry of human metabolites of benzo[ghi]perylene (B[ghi]P) investigated using electro-optical arrays and DNA/microsome biocolloid reactors with LC-MS/MS.

Authors:  Shenmin Pan; Dandan Li; Linlin Zhao; John B Schenkman; James F Rusling
Journal:  Chem Res Toxicol       Date:  2013-08-08       Impact factor: 3.739

  4 in total

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