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Literature DB >> 18802562

Highly stable dendritic trityl radicals as oxygen and pH probe.

Yangping Liu¹, Frederick A Villamena, Jay L Zweier.

Abstract

Novel dendritic trityl radicals (DTR1 and DTR2) with a TAM radical core, PAMAM branching and carboxylate exterior surface exhibit high stability towards oxidoreductants as evidenced by their electrochemical and EPR properties, offering potential application as dual oxygen and pH probe.

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Year: 2008 PMID： 18802562 PMCID： PMC2830062 DOI： 10.1039/b807406b

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

19 in total

1. Dendritic Encapsulation of Function: Applying Nature's Site Isolation Principle from Biomimetics to Materials Science.

Authors: Stefan Hecht; Jean M. J. Fréchet
Journal: Angew Chem Int Ed Engl Date: 2001-01-05 Impact factor: 15.336

2. Fast 3D spatial EPR imaging using spiral magnetic field gradient.

Authors: Yuanmu Deng; Sergy Petryakov; Guanglong He; Eric Kesselring; Periannan Kuppusamy; Jay L Zweier
Journal: J Magn Reson Date: 2007-01-08 Impact factor: 2.229

3. Trityl radicals as persistent dual function pH and oxygen probes for in vivo electron paramagnetic resonance spectroscopy and imaging: concept and experiment.

Authors: Andrey A Bobko; Ilirian Dhimitruka; Jay L Zweier; Valery V Khramtsov
Journal: J Am Chem Soc Date: 2007-05-19 Impact factor: 15.419

4. Direct measurement of free radical generation following reperfusion of ischemic myocardium.

Authors: J L Zweier; J T Flaherty; M L Weisfeldt
Journal: Proc Natl Acad Sci U S A Date: 1987-03 Impact factor: 11.205

5. Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo.

Authors: N Malik; R Wiwattanapatapee; R Klopsch; K Lorenz; H Frey; J W Weener; E W Meijer; W Paulus; R Duncan
Journal: J Control Release Date: 2000-03-01 Impact factor: 9.776

6. Attenuating electron-transfer rates via dendrimer encapsulation: the case of metal tris(bipyridine) core dendrimers.

Authors: Young-Rae Hong; Christopher B Gorman
Journal: Langmuir Date: 2006-12-05 Impact factor: 3.882

7. Application of a trityl-based radical probe for measuring superoxide.

Authors: Cëcile Rizzi; Alexandre Samouilov; Vijay Kumar Kutala; Narasimham L Parinandi; Jay L Zweier; Periannan Kuppusamy
Journal: Free Radic Biol Med Date: 2003-12-15 Impact factor: 7.376

8. Phosphorescent oxygen sensor with dendritic protection and two-photon absorbing antenna.

Authors: Raymond P Briñas; Thomas Troxler; Robin M Hochstrasser; Sergei A Vinogradov
Journal: J Am Chem Soc Date: 2005-08-24 Impact factor: 15.419

Review 9. Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy.

Authors: Aditi C Kulkarni; Periannan Kuppusamy; Narasimham Parinandi
Journal: Antioxid Redox Signal Date: 2007-10 Impact factor: 8.401

10. Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging.

Authors: Ilirian Dhimitruka; Murugesan Velayutham; Andrey A Bobko; Valery V Khramtsov; Frederick A Villamena; Christopher M Hadad; Jay L Zweier
Journal: Bioorg Med Chem Lett Date: 2007-10-17 Impact factor: 2.823

14 in total

1. Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical.

Authors: Ilirian Dhimitruka; Olga Grigorieva; Jay L Zweier; Valery V Khramtsov
Journal: Bioorg Med Chem Lett Date: 2010-05-07 Impact factor: 2.823

2. Fast gated EPR imaging of the beating heart: spatiotemporally resolved 3D imaging of free-radical distribution during the cardiac cycle.

Authors: Zhiyu Chen; Levy A Reyes; David H Johnson; Murugesan Velayutham; Changjun Yang; Alexandre Samouilov; Jay L Zweier
Journal: Magn Reson Med Date: 2012-04-03 Impact factor: 4.668

10. Trityl-nitroxide biradicals as unique molecular probes for the simultaneous measurement of redox status and oxygenation.

Authors: Yangping Liu; Frederick A Villamena; Antal Rockenbauer; Jay L Zweier
Journal: Chem Commun (Camb) Date: 2009-11-18 Impact factor: 6.222

Highly stable dendritic trityl radicals as oxygen and pH probe.

1. Dendritic Encapsulation of Function: Applying Nature's Site Isolation Principle from Biomimetics to Materials Science.

2. Fast 3D spatial EPR imaging using spiral magnetic field gradient.

3. Trityl radicals as persistent dual function pH and oxygen probes for in vivo electron paramagnetic resonance spectroscopy and imaging: concept and experiment.

4. Direct measurement of free radical generation following reperfusion of ischemic myocardium.

5. Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo.

6. Attenuating electron-transfer rates via dendrimer encapsulation: the case of metal tris(bipyridine) core dendrimers.

7. Application of a trityl-based radical probe for measuring superoxide.

8. Phosphorescent oxygen sensor with dendritic protection and two-photon absorbing antenna.

Review 9. Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy.

10. Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging.

1. Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical.

2. Fast gated EPR imaging of the beating heart: spatiotemporally resolved 3D imaging of free-radical distribution during the cardiac cycle.

3. Synthesis of trityl radical-conjugated disulfide biradicals for measurement of thiol concentration.

4. Dextran-conjugated tetrathiatriarylmethyl radicals as biocompatible spin probes for EPR spectroscopy and imaging.

5. Chemical exchange induced Hahn echo modulation in pulsed electron paramagnetic resonance experiment.

6. Trityl radicals in perfluorocarbon emulsions as stable, sensitive, and biocompatible oximetry probes.

7. Characterization of the Binding of the Finland Trityl Radical with Bovine Serum Albumin.

8. Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe.

9. Esterified trityl radicals as intracellular oxygen probes.

10. Trityl-nitroxide biradicals as unique molecular probes for the simultaneous measurement of redox status and oxygenation.