Literature DB >> 20537895

Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical.

Ilirian Dhimitruka1, Olga Grigorieva, Jay L Zweier, Valery V Khramtsov.   

Abstract

Substituted trityl radicals are important spin probes for functional electron paramagnetic resonance spectroscopy and imaging including oxygen and pH mapping in vivo. Here we report the synthetic procedure for large scale synthesis of deuterated Finland trityl radical with superior EPR spectral properties and higher sensitivity towards oxygen concentrations in solution. Additionally Finland trityl radicals substituted with linkers suitable for attaching peptide, or other synthetic precursors have been synthesized. The effect of deutero-substitution on EPR spectra of homologous derivatives has been evaluated. The compounds are potential candidates for targeted spin probes in EPR imaging. 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20537895      PMCID： PMC2889913          DOI： 10.1016/j.bmcl.2010.05.006

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  18 in total

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