Jackie K Gollan1, Denada Hoxha2, Dietta Chihade2, Mark E Pflieger3, Laina Rosebrock2, John Cacioppo4. 1. Northwestern University Feinberg School of Medicine, Asher Center for the Study and Treatment of Depressive Disorders, 676 North St. Clair Street, Chicago, IL 60611, USA. Electronic address: j-gollan@northwestern.edu. 2. Northwestern University Feinberg School of Medicine, Asher Center for the Study and Treatment of Depressive Disorders, 676 North St. Clair Street, Chicago, IL 60611, USA. 3. Source Signal Imaging, Inc., 7171 Alvarado, Suite 103, La Mesa, CA 91942-8998, USA. 4. The University of Chicago, Center for Social Neuroscience, Department of Psychology, 5848 South University Avenue, Chicago, IL 60637, USA.
Abstract
BACKGROUND: Mid-frontal and mid-lateral (F3/F4 and F7/F8) EEG asymmetry has been associated with motivation and affect. We examined alpha EEG asymmetry in depressed and healthy participants before and after Behavioral Activation treatment for depression; examined the association between alpha EEG asymmetry and motivational systems and affect; and evaluated the utility of alpha EEG asymmetry in predicting remission. METHODS: Depressed (n=37) and healthy participants (n=35) were assessed before and after treatment using a clinical interview, a task to measure baseline EEG, and questionnaires of behavioral activation and inhibition, avoidance, and affect. RESULTS: Alpha EEG asymmetry was significantly higher in depressed than healthy participants at pre-treatment, positively correlated with negative affect and behavioral inhibition, and inversely correlated with lower behavioral activation sensitivity. CONCLUSIONS: Heightened alpha EEG asymmetry in depressed participants was significantly associated with increased behavioral inhibition and negative emotion and was independent of clinical remission.
BACKGROUND: Mid-frontal and mid-lateral (F3/F4 and F7/F8) EEG asymmetry has been associated with motivation and affect. We examined alpha EEG asymmetry in depressed and healthy participants before and after Behavioral Activation treatment for depression; examined the association between alpha EEG asymmetry and motivational systems and affect; and evaluated the utility of alpha EEG asymmetry in predicting remission. METHODS:Depressed (n=37) and healthy participants (n=35) were assessed before and after treatment using a clinical interview, a task to measure baseline EEG, and questionnaires of behavioral activation and inhibition, avoidance, and affect. RESULTS: Alpha EEG asymmetry was significantly higher in depressed than healthy participants at pre-treatment, positively correlated with negative affect and behavioral inhibition, and inversely correlated with lower behavioral activation sensitivity. CONCLUSIONS: Heightened alpha EEG asymmetry in depressedparticipants was significantly associated with increased behavioral inhibition and negative emotion and was independent of clinical remission.
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