BACKGROUND AND PURPOSE: Periodontal disease results in tooth loss, may contribute to systemic inflammation, and is associated with stroke. We examined cross-sectional associations between tooth loss, inflammation markers, stroke, race, and geographic region among participants in the reasons for geographic and racial differences in stroke (REGARDS) study of whites and blacks > or =45 years. METHODS: We studied 24,393 participants. Associations of tooth loss and inflammation markers (C-reactive protein (CRP), white blood cell count (WBC) and albumin) were examined by linear regression, and associations of tooth loss with geographic region, race, and prevalent stroke by logistic regression. RESULTS: Compared to whites, blacks had an odds ratio of 1.48 (95% confidence interval 1.37-1.60) of having more teeth lost. There were no geographic differences in tooth loss. Compared to no tooth loss, those with 17-32 teeth lost had 1.17mg/L higher CRP (p<0.0001) and 0.18x10(9)/L higher WBC (p=0.008), did not differ in albumin, and had an odds ratio of prevalent stroke of 1.28 (1.09-1.49). Those with 1-16 teeth lost did not differ in CRP and WBC, had 0.03g/dL higher albumin (p=0.004), and had no increased stroke prevalence. CRP or WBC did not attenuate associations between tooth loss and stroke. CONCLUSIONS: Tooth loss, which varied with race, but not region of residence, was associated with inflammation markers and stroke. The latter association was not confounded by inflammation markers.
BACKGROUND AND PURPOSE:Periodontal disease results in tooth loss, may contribute to systemic inflammation, and is associated with stroke. We examined cross-sectional associations between tooth loss, inflammation markers, stroke, race, and geographic region among participants in the reasons for geographic and racial differences in stroke (REGARDS) study of whites and blacks > or =45 years. METHODS: We studied 24,393 participants. Associations of tooth loss and inflammation markers (C-reactive protein (CRP), white blood cell count (WBC) and albumin) were examined by linear regression, and associations of tooth loss with geographic region, race, and prevalent stroke by logistic regression. RESULTS: Compared to whites, blacks had an odds ratio of 1.48 (95% confidence interval 1.37-1.60) of having more teeth lost. There were no geographic differences in tooth loss. Compared to no tooth loss, those with 17-32 teeth lost had 1.17mg/L higher CRP (p<0.0001) and 0.18x10(9)/L higher WBC (p=0.008), did not differ in albumin, and had an odds ratio of prevalent stroke of 1.28 (1.09-1.49). Those with 1-16 teeth lost did not differ in CRP and WBC, had 0.03g/dL higher albumin (p=0.004), and had no increased stroke prevalence. CRP or WBC did not attenuate associations between tooth loss and stroke. CONCLUSIONS:Tooth loss, which varied with race, but not region of residence, was associated with inflammation markers and stroke. The latter association was not confounded by inflammation markers.
Authors: Moïse Desvarieux; Ryan T Demmer; Tatjana Rundek; Bernadette Boden-Albala; David R Jacobs; Panos N Papapanou; Ralph L Sacco Journal: Stroke Date: 2003-07-31 Impact factor: 7.914
Authors: Virginia J Howard; Mary Cushman; Leavonne Pulley; Camilo R Gomez; Rodney C Go; Ronald J Prineas; Andra Graham; Claudia S Moy; George Howard Journal: Neuroepidemiology Date: 2005-06-29 Impact factor: 3.282
Authors: Faisal M Shuaib; Raegan W Durant; Gaurav Parmar; Todd M Brown; David L Roth; Martha Hovater; Jewell H Halanych; James M Shikany; George Howard; Monika M Safford Journal: J Health Care Poor Underserved Date: 2012-05
Authors: Edmond K Kabagambe; Suzanne E Judd; Virginia J Howard; Neil A Zakai; Nancy S Jenny; Matthew Hsieh; David G Warnock; Mary Cushman Journal: Am J Epidemiol Date: 2011-06-17 Impact factor: 4.897
Authors: L H Liu; E M Li; S L Zhong; Y Q Li; Z Y Yang; R Kang; S K Zhao; F T Li; S P Wan; Z G Zhao Journal: Int J Impot Res Date: 2016-11-10 Impact factor: 2.896
Authors: Yago Leira; Juan Seoane; Miguel Blanco; Manuel Rodríguez-Yáñez; Bahi Takkouche; Juan Blanco; José Castillo Journal: Eur J Epidemiol Date: 2016-06-14 Impact factor: 8.082
Authors: Bei Wu; Eric A Goedereis; Richard J Crout; Brenda L Plassman; Elizabeth A DiNapoli; Daniel W McNeil; Michael Wiener; Martin L Boone; R Constance Wiener; Elizabeth Kao; Lina Bai Journal: Spec Care Dentist Date: 2010-08-17
Authors: Douglas R Farquhar; Kimon Divaris; Angela L Mazul; Mark C Weissler; Jose P Zevallos; Andrew F Olshan Journal: Oral Oncol Date: 2017-10 Impact factor: 5.337
Authors: Hanna Tuominen; Mikko Taina; Mirja Puranen; Juha Onatsu; Sisko Huumonen; Ritva Vanninen Journal: In Vivo Date: 2020 Sep-Oct Impact factor: 2.155