Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP.

Literature DB >> 18799311

Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP.

Hongbin Yan¹, Xiaolu Wang, Rhonda KuoLee, Wangxue Chen.

Abstract

The synthesis of mono- and bisphosphorothioate analogues of 3',5'-cyclic diguanylic acid (cdiGMP) via the modified H-phosphonate chemistry is reported. The immunostimulatory properties of these analogues were compared with those of cdiGMP.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18799311 DOI： 10.1016/j.bmcl.2008.08.088

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

10 in total

1. STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.

Authors: Juan Fu; David B Kanne; Meredith Leong; Laura Hix Glickman; Sarah M McWhirter; Edward Lemmens; Ken Mechette; Justin J Leong; Peter Lauer; Weiqun Liu; Kelsey E Sivick; Qi Zeng; Kevin C Soares; Lei Zheng; Daniel A Portnoy; Joshua J Woodward; Drew M Pardoll; Thomas W Dubensky; Young Kim
Journal: Sci Transl Med Date: 2015-04-15 Impact factor: 17.956

Review 2. Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants.

Authors: Thomas W Dubensky; David B Kanne; Meredith L Leong
Journal: Ther Adv Vaccines Date: 2013-11

3. Synthesis of c-di-GMP analogs with thiourea, urea, carbodiimide, and guanidinium linkages.

Authors: Barbara L Gaffney; Roger A Jones
Journal: Org Lett Date: 2013-12-06 Impact factor: 6.005

4. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.

Authors: Leticia Corrales; Laura Hix Glickman; Sarah M McWhirter; David B Kanne; Kelsey E Sivick; George E Katibah; Seng-Ryong Woo; Edward Lemmens; Tamara Banda; Justin J Leong; Ken Metchette; Thomas W Dubensky; Thomas F Gajewski
Journal: Cell Rep Date: 2015-05-07 Impact factor: 9.423

5. A kinase-cGAS cascade to synthesize a therapeutic STING activator.

Authors: John A McIntosh; Zhijian Liu; Brian M Andresen; Nastaran Salehi Marzijarani; Jeffrey C Moore; Nicholas M Marshall; Margie Borra-Garske; Jennifer V Obligacion; Patrick S Fier; Feng Peng; Jacob H Forstater; Matthew S Winston; Chihui An; Wonsuk Chang; Jongwon Lim; Mark A Huffman; Steven P Miller; Fuh-Rong Tsay; Michael D Altman; Charles A Lesburg; Dietrich Steinhuebel; B Wesley Trotter; Jared N Cumming; Alan Northrup; Xiaodong Bu; Benjamin F Mann; Mirlinda Biba; Kaori Hiraga; Grant S Murphy; Joshua N Kolev; Amanda Makarewicz; Weilan Pan; Iman Farasat; Rachel S Bade; Kevin Stone; Da Duan; Oscar Alvizo; Donovan Adpressa; Erik Guetschow; Erik Hoyt; Erik L Regalado; Steve Castro; Nelo Rivera; Joseph P Smith; Fengqiang Wang; Alejandro Crespo; Deeptak Verma; Stephanus Axnanda; Zachary E X Dance; Paul N Devine; David Tschaen; Keith A Canada; Paul G Bulger; Benjamin D Sherry; Matthew D Truppo; Rebecca T Ruck; Louis-Charles Campeau; David Jonathan Bennett; Guy R Humphrey; Kevin R Campos; Matthew L Maddess
Journal: Nature Date: 2022-03-16 Impact factor: 49.962

Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP.

1. STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.

Review 2. Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants.

3. Synthesis of c-di-GMP analogs with thiourea, urea, carbodiimide, and guanidinium linkages.

4. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.

5. A kinase-cGAS cascade to synthesize a therapeutic STING activator.

Review 6. Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy.

Review 7. Biomolecular Mechanisms of Pseudomonas aeruginosa and Escherichia coli Biofilm Formation.

8. 2'-Fluoro-c-di-GMP as an oral vaccine adjuvant.

Review 9. Nanodelivery of STING agonists against cancer and infectious diseases.

Review 10. Small Molecules Drive Big Improvements in Immuno-Oncology Therapies.