Literature DB >> 18798610

Whole structure-activity relationships of the fat-accumulation inhibitor (-)-ternatin: recognition of the importance of each amino acid residue.

Kenichiro Shimokawa1, Yoshiaki Iwase, Ryoka Miwa, Kaoru Yamada, Daisuke Uemura.   

Abstract

A series of Ala and Aoc analogues of (-)-ternatin were prepared, and their bioactivities were assessed by a fat-accumulation inhibition assay using 3T3-L1 adipocytes, which led to the discovery of key structure-activity relationships (SAR).

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Year:  2008        PMID： 18798610     DOI： 10.1021/jm800741n

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

Review 1.  Advances in transition metal (Pd, Ni, Fe)-catalyzed cross-coupling reactions using alkyl-organometallics as reaction partners.

Authors:  Ranjan Jana; Tejas P Pathak; Matthew S Sigman
Journal:  Chem Rev       Date:  2011-02-14       Impact factor: 60.622

2.  Structural rationale for the cross-resistance of tumor cells bearing the A399V variant of elongation factor eEF1A1 to the structurally unrelated didemnin B, ternatin, nannocystin A and ansatrienin B.

Authors:  Pedro A Sánchez-Murcia; Álvaro Cortés-Cabrera; Federico Gago
Journal:  J Comput Aided Mol Des       Date:  2017-09-12       Impact factor: 3.686

3.  Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum.

Authors:  Celso Almeida; Ekaterina Eguereva; Stefan Kehraus; Carsten Siering; Gabriele M König
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

4.  Marilones A-C, phthalides from the sponge-derived fungus Stachylidium sp.

Authors:  Celso Almeida; Stefan Kehraus; Miguel Prudêncio; Gabriele M König
Journal:  Beilstein J Org Chem       Date:  2011-12-05       Impact factor: 2.883

5.  Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.

Authors:  Jordan D Carelli; Steven G Sethofer; Geoffrey A Smith; Howard R Miller; Jillian L Simard; William C Merrick; Rishi K Jain; Nathan T Ross; Jack Taunton
Journal:  Elife       Date:  2015-12-10       Impact factor: 8.140
  5 in total

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