Literature DB >> 18797858

Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual.

Andrea Gaedigk1, Dorothee Frank, Uwe Fuhr.   

Abstract

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Year:  2008        PMID： 18797858     DOI： 10.1007/s00228-008-0559-6

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


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  9 in total

1.  The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6.

Authors:  T Fukuda; Y Nishida; S Imaoka; T Hiroi; M Naohara; Y Funae; J Azuma
Journal:  Arch Biochem Biophys       Date:  2000-08-15       Impact factor: 4.013

2.  Sequence-based analysis of the CYP2D6*36-CYP2D6*10 tandem-type arrangement, a major CYP2D6*10 haplotype in the Japanese population.

Authors:  Akiko Soyama; Yoshiro Saito; Takashi Kubo; Atsuko Miyajima; Yasuo Ohno; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Shogo Ozawa; Jun-ichi Sawada
Journal:  Drug Metab Pharmacokinet       Date:  2006-06       Impact factor: 3.614

3.  Impaired expression of CYP2D6 in intermediate metabolizers carrying the *41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events.

Authors:  Claudia Toscano; Kathrin Klein; Julia Blievernicht; Elke Schaeffeler; Tanja Saussele; Sebastian Raimundo; Michel Eichelbaum; Matthias Schwab; Ulrich M Zanger
Journal:  Pharmacogenet Genomics       Date:  2006-10       Impact factor: 2.089

4.  The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.

Authors:  A Gaedigk; S D Simon; R E Pearce; L D Bradford; M J Kennedy; J S Leeder
Journal:  Clin Pharmacol Ther       Date:  2007-10-31       Impact factor: 6.875

5.  Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers.

Authors:  D Tomalik-Scharte; A Jetter; M Kinzig-Schippers; A Skott; F Sörgel; T Klaassen; D Kasel; S Harlfinger; O Doroshyenko; D Frank; J Kirchheiner; M Bräter; K Richter; T Gramatté; U Fuhr
Journal:  Drug Metab Dispos       Date:  2005-09-23       Impact factor: 3.922

6.  Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.

Authors:  Hongwu Shen; Minxia M He; Houfu Liu; Steven A Wrighton; Li Wang; Bin Guo; Chuan Li
Journal:  Drug Metab Dispos       Date:  2007-04-30       Impact factor: 3.922

7.  A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects.

Authors:  Sebastian Raimundo; Claudia Toscano; Kathrin Klein; Joachim Fischer; Ernst-Ulrich Griese; Michel Eichelbaum; Matthias Schwab; Ulrich M Zanger
Journal:  Clin Pharmacol Ther       Date:  2004-08       Impact factor: 6.875

Review 8.  Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.

Authors:  Ulrich M Zanger; Sebastian Raimundo; Michel Eichelbaum
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-11-15       Impact factor: 3.000

9.  Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients.

Authors:  C Wyen; U Fuhr; D Frank; R E Aarnoutse; T Klaassen; A Lazar; A Seeringer; O Doroshyenko; J C Kirchheiner; F Abdulrazik; N Schmeisser; C Lehmann; W Hein; E Schömig; D M Burger; G Fätkenheuer; A Jetter
Journal:  Clin Pharmacol Ther       Date:  2008-01-09       Impact factor: 6.875
  9 in total
  8 in total

1.  Defining screening panel of functional variants of CYP1A1, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 genes in Serbian population.

Authors:  Ivan Skadrić; Oliver Stojković
Journal:  Int J Legal Med       Date:  2019-12-20       Impact factor: 2.686

2.  Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes.

Authors:  Alison Fohner; LeeAnna I Muzquiz; Melissa A Austin; Andrea Gaedigk; Adam Gordon; Timothy Thornton; Mark J Rieder; Mark A Pershouse; Elizabeth A Putnam; Kevin Howlett; Patrick Beatty; Kenneth E Thummel; Erica L Woodahl
Journal:  Pharmacogenet Genomics       Date:  2013-08       Impact factor: 2.089

3.  CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele.

Authors:  Andrea Gaedigk; Amanda K Riffel; J Steven Leeder
Journal:  J Mol Diagn       Date:  2015-09-01       Impact factor: 5.568

4.  Intronic polymorphisms of cytochromes P450.

Authors:  Magnus Ingelman-Sundberg; Sarah C Sim
Journal:  Hum Genomics       Date:  2010-08       Impact factor: 4.639

Review 5.  Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and the European Society for Pharmacogenomics and Personalized Therapy.

Authors:  Victoria M Pratt; Larisa H Cavallari; Andria L Del Tredici; Andrea Gaedigk; Houda Hachad; Yuan Ji; Lisa V Kalman; Reynold C Ly; Ann M Moyer; Stuart A Scott; R H N van Schaik; Michelle Whirl-Carrillo; Karen E Weck
Journal:  J Mol Diagn       Date:  2021-06-10       Impact factor: 5.341

6.  Methodology for clinical genotyping of CYP2D6 and CYP2C19.

Authors:  Beatriz Carvalho Henriques; Avery Buchner; Xiuying Hu; Yabing Wang; Vasyl Yavorskyy; Keanna Wallace; Rachael Dong; Kristina Martens; Michael S Carr; Bahareh Behroozi Asl; Joshua Hague; Sudhakar Sivapalan; Wolfgang Maier; Mojca Z Dernovsek; Neven Henigsberg; Joanna Hauser; Daniel Souery; Annamaria Cattaneo; Ole Mors; Marcella Rietschel; Gerald Pfeffer; Stacey Hume; Katherine J Aitchison
Journal:  Transl Psychiatry       Date:  2021-11-22       Impact factor: 6.222

Review 7.  Frequencies of CYP2D6 genetic polymorphisms in Arab populations.

Authors:  Mousa Alali; Wouroud Ismail Al-Khalil; Sara Rijjal; Lana Al-Salhi; Maher Saifo; Lama A Youssef
Journal:  Hum Genomics       Date:  2022-02-05       Impact factor: 4.639

8.  The frequencies of CYP2D6 alleles and their impact on clinical outcomes of adjuvant tamoxifen therapy in Syrian breast cancer patients.

Authors:  Wouroud Ismail Al-Khalil; Lana Al-Salhi; Sara Rijjal; Majd Aljamali; Lama A Youssef
Journal:  BMC Cancer       Date:  2022-10-15       Impact factor: 4.638
  8 in total

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