Literature DB >> 18797474

Modelling and analysis of gene regulatory networks.

Guy Karlebach1, Ron Shamir.   

Abstract

Gene regulatory networks have an important role in every process of life, including cell differentiation, metabolism, the cell cycle and signal transduction. By understanding the dynamics of these networks we can shed light on the mechanisms of diseases that occur when these cellular processes are dysregulated. Accurate prediction of the behaviour of regulatory networks will also speed up biotechnological projects, as such predictions are quicker and cheaper than lab experiments. Computational methods, both for supporting the development of network models and for the analysis of their functionality, have already proved to be a valuable research tool.

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Year:  2008        PMID: 18797474     DOI: 10.1038/nrm2503

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN: 1471-0072            Impact factor:   94.444


  279 in total

1.  Matrix Factorization for Transcriptional Regulatory Network Inference.

Authors:  Michael F Ochs; Elana J Fertig
Journal:  IEEE Symp Comput Intell Bioinforma Comput Biol Proc       Date:  2012-05

Review 2.  Epigenetic memories: structural marks or active circuits?

Authors:  Floriane Nicol-Benoît; Pascale Le-Goff; Yves Le-Dréan; Florence Demay; Farzad Pakdel; Gilles Flouriot; Denis Michel
Journal:  Cell Mol Life Sci       Date:  2012-02-14       Impact factor: 9.261

3.  The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops.

Authors:  Qing Xie; Ales Cvekl
Journal:  J Biol Chem       Date:  2011-10-13       Impact factor: 5.157

Review 4.  Advantages and limitations of current network inference methods.

Authors:  Riet De Smet; Kathleen Marchal
Journal:  Nat Rev Microbiol       Date:  2010-08-31       Impact factor: 60.633

5.  A novel knowledge-driven systems biology approach for phenotype prediction upon genetic intervention.

Authors:  Rui Chang; Robert Shoemaker; Wei Wang
Journal:  IEEE/ACM Trans Comput Biol Bioinform       Date:  2011 Sep-Oct       Impact factor: 3.710

Review 6.  Systems biophysics of gene expression.

Authors:  Jose M G Vilar; Leonor Saiz
Journal:  Biophys J       Date:  2013-06-18       Impact factor: 4.033

7.  Signaling hypergraphs.

Authors:  Anna Ritz; Allison N Tegge; Hyunju Kim; Christopher L Poirel; T M Murali
Journal:  Trends Biotechnol       Date:  2014-05-22       Impact factor: 19.536

Review 8.  Mechanisms and evolution of control logic in prokaryotic transcriptional regulation.

Authors:  Sacha A F T van Hijum; Marnix H Medema; Oscar P Kuipers
Journal:  Microbiol Mol Biol Rev       Date:  2009-09       Impact factor: 11.056

9.  Combinatorial regulation of lipoprotein lipase by microRNAs during mouse adipogenesis.

Authors:  Maria Bouvy-Liivrand; Merja Heinäniemi; Elisabeth John; Jochen G Schneider; Thomas Sauter; Lasse Sinkkonen
Journal:  RNA Biol       Date:  2014-01-16       Impact factor: 4.652

Review 10.  Navigating the network: signaling cross-talk in hematopoietic cells.

Authors:  Iain D C Fraser; Ronald N Germain
Journal:  Nat Immunol       Date:  2009-03-19       Impact factor: 25.606

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