L Van Oudenhove1, S Kindt, R Vos, B Coulie, J Tack. 1. Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium.
Abstract
BACKGROUND: Previous studies have suggested involvement of 5HT(1) receptors in the control of gastric tone. AIM: To study the effect of buspirone, a 5HT(1A) agonist, on gastric sensorimotor function in healthy volunteers. METHODS:Ten healthy volunteers (six males and four females, ages 20-29 years) participated in a barostat study evaluating the influence of single oral doses of buspirone (5, 10, 20, 30 and 40 mg) on tone and sensitivity of the proximal stomach. In addition, the effect of placebo or the three lowest doses of buspirone on gastric emptying was assessed using a solid and liquid gastric emptying breath test. RESULTS: Compared to preadministration volumes, buspirone increased proximal stomach volumes in a dose-dependent manner, with significant fundic relaxation after 30 and 40 mg doses (intra-balloon volume increases of respectively 258 +/- 80 mL and 273 +/- 49 mL, P < or = 0.05). Pressure thresholds during gastric distention were not altered, but corresponding intraballoon volumes were significantly increased after 30 and 40 mg doses (respective discomfort volumes 596 +/- 73vs. 791 +/- 87 mL and 630 +/- 73 vs.741 +/- 60 mL, both P < 0.05). Buspirone significantly slowed solid and liquid gastric emptying at the 20-mg dose. CONCLUSION:Buspirone dose-dependently relaxes the proximal stomach in the fasting state and decreases the gastric emptying rate in healthy volunteers.
RCT Entities:
BACKGROUND: Previous studies have suggested involvement of 5HT(1) receptors in the control of gastric tone. AIM: To study the effect of buspirone, a 5HT(1A) agonist, on gastric sensorimotor function in healthy volunteers. METHODS: Ten healthy volunteers (six males and four females, ages 20-29 years) participated in a barostat study evaluating the influence of single oral doses of buspirone (5, 10, 20, 30 and 40 mg) on tone and sensitivity of the proximal stomach. In addition, the effect of placebo or the three lowest doses of buspirone on gastric emptying was assessed using a solid and liquid gastric emptying breath test. RESULTS: Compared to preadministration volumes, buspirone increased proximal stomach volumes in a dose-dependent manner, with significant fundic relaxation after 30 and 40 mg doses (intra-balloon volume increases of respectively 258 +/- 80 mL and 273 +/- 49 mL, P < or = 0.05). Pressure thresholds during gastric distention were not altered, but corresponding intraballoon volumes were significantly increased after 30 and 40 mg doses (respective discomfort volumes 596 +/- 73 vs. 791 +/- 87 mL and 630 +/- 73 vs.741 +/- 60 mL, both P < 0.05). Buspirone significantly slowed solid and liquid gastric emptying at the 20-mg dose. CONCLUSION:Buspirone dose-dependently relaxes the proximal stomach in the fasting state and decreases the gastric emptying rate in healthy volunteers.
Authors: Lucas Wauters; Ram Dickman; Vasile Drug; Agata Mulak; Jordi Serra; Paul Enck; Jan Tack; Anna Accarino; Giovanni Barbara; Serhat Bor; Benoit Coffin; Maura Corsetti; Heiko De Schepper; Dan Dumitrascu; Adam Farmer; Guillaume Gourcerol; Goran Hauser; Trygve Hausken; George Karamanolis; Daniel Keszthelyi; Carolin Malagelada; Tomislav Milosavljevic; Jean Muris; Colm O'Morain; Athanassos Papathanasopoulos; Daniel Pohl; Diana Rumyantseva; Giovanni Sarnelli; Edoardo Savarino; Jolien Schol; Arkady Sheptulin; Annemieke Smet; Andreas Stengel; Olga Storonova; Martin Storr; Hans Törnblom; Tim Vanuytsel; Monica Velosa; Marek Waluga; Natalia Zarate; Frank Zerbib Journal: United European Gastroenterol J Date: 2021-04 Impact factor: 4.623
Authors: R H Hunt; M Camilleri; S E Crowe; E M El-Omar; J G Fox; E J Kuipers; P Malfertheiner; K E L McColl; D M Pritchard; M Rugge; A Sonnenberg; K Sugano; J Tack Journal: Gut Date: 2015-09-04 Impact factor: 23.059