Literature DB >> 18791035

African trypanosomes contain 5-methylcytosine in nuclear DNA.

Kevin T Militello1, Ping Wang, Sangeeta K Jayakar, Rebecca L Pietrasik, Christopher D Dupont, Kristi Dodd, Anthony M King, Paul R Valenti.   

Abstract

It is currently unclear if there are modified DNA bases in Trypanosoma brucei other than J-base. We identify herein a cytosine-5 DNA methyltransferase gene and report the presence and location of 5-methylcytosine in genomic DNA. Our data demonstrate that African trypanosomes contain a functional cytosine DNA methylation pathway.

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Year:  2008        PMID： 18791035      PMCID： PMC2583544          DOI： 10.1128/EC.00198-08

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  26 in total

1.  Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry.

Authors:  Liguo Song; Smitha R James; Latif Kazim; Adam R Karpf
Journal:  Anal Chem       Date:  2005-01-15       Impact factor: 6.986

2.  Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells.

Authors:  Adam R Karpf; Sei-ichi Matsui
Journal:  Cancer Res       Date:  2005-10-01       Impact factor: 12.701

3.  Developmental changes in DNA methylation of the two tobacco pollen nuclei during maturation.

Authors:  E J Oakeley; A Podestà; J P Jost
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

4.  Predictive motifs derived from cytosine methyltransferases.

Authors:  J Pósfai; A S Bhagwat; G Pósfai; R J Roberts
Journal:  Nucleic Acids Res       Date:  1989-04-11       Impact factor: 16.971

Review 5.  Eukaryotic cytosine methyltransferases.

Authors:  Mary Grace Goll; Timothy H Bestor
Journal:  Annu Rev Biochem       Date:  2005       Impact factor: 23.643

6.  The identification of hydroxymethyluracil in DNA of Trypanosoma brucei.

Authors:  J H Gommers-Ampt; A J Teixeira; G van de Werken; W J van Dijk; P Borst
Journal:  Nucleic Acids Res       Date:  1993-05-11       Impact factor: 16.971

7.  Cloning and characterization of the dcm locus of Escherichia coli K-12.

Authors:  A S Bhagwat; A Sohail; R J Roberts
Journal:  J Bacteriol       Date:  1986-06       Impact factor: 3.490

8.  Developmentally regulated DNA methylation in Dictyostelium discoideum.

Authors:  Mariko Katoh; Tomaz Curk; Qikai Xu; Blaz Zupan; Adam Kuspa; Gad Shaulsky
Journal:  Eukaryot Cell       Date:  2006-01

9.  The genome of the African trypanosome Trypanosoma brucei.

Authors:  Matthew Berriman; Elodie Ghedin; Christiane Hertz-Fowler; Gaëlle Blandin; Hubert Renauld; Daniella C Bartholomeu; Nicola J Lennard; Elisabet Caler; Nancy E Hamlin; Brian Haas; Ulrike Böhme; Linda Hannick; Martin A Aslett; Joshua Shallom; Lucio Marcello; Lihua Hou; Bill Wickstead; U Cecilia M Alsmark; Claire Arrowsmith; Rebecca J Atkin; Andrew J Barron; Frederic Bringaud; Karen Brooks; Mark Carrington; Inna Cherevach; Tracey-Jane Chillingworth; Carol Churcher; Louise N Clark; Craig H Corton; Ann Cronin; Rob M Davies; Jonathon Doggett; Appolinaire Djikeng; Tamara Feldblyum; Mark C Field; Audrey Fraser; Ian Goodhead; Zahra Hance; David Harper; Barbara R Harris; Heidi Hauser; Jessica Hostetler; Al Ivens; Kay Jagels; David Johnson; Justin Johnson; Kristine Jones; Arnaud X Kerhornou; Hean Koo; Natasha Larke; Scott Landfear; Christopher Larkin; Vanessa Leech; Alexandra Line; Angela Lord; Annette Macleod; Paul J Mooney; Sharon Moule; David M A Martin; Gareth W Morgan; Karen Mungall; Halina Norbertczak; Doug Ormond; Grace Pai; Chris S Peacock; Jeremy Peterson; Michael A Quail; Ester Rabbinowitsch; Marie-Adele Rajandream; Chris Reitter; Steven L Salzberg; Mandy Sanders; Seth Schobel; Sarah Sharp; Mark Simmonds; Anjana J Simpson; Luke Tallon; C Michael R Turner; Andrew Tait; Adrian R Tivey; Susan Van Aken; Danielle Walker; David Wanless; Shiliang Wang; Brian White; Owen White; Sally Whitehead; John Woodward; Jennifer Wortman; Mark D Adams; T Martin Embley; Keith Gull; Elisabetta Ullu; J David Barry; Alan H Fairlamb; Fred Opperdoes; Barclay G Barrell; John E Donelson; Neil Hall; Claire M Fraser; Sara E Melville; Najib M El-Sayed
Journal:  Science       Date:  2005-07-15       Impact factor: 47.728

Review 10.  Cytosine methylation and the ecology of intragenomic parasites.

Authors:  J A Yoder; C P Walsh; T H Bestor
Journal:  Trends Genet       Date:  1997-08       Impact factor: 11.639
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  11 in total

Review 1.  Epigenetic regulation in African trypanosomes: a new kid on the block.

Authors:  Luisa M Figueiredo; George A M Cross; Christian J Janzen
Journal:  Nat Rev Microbiol       Date:  2009-07       Impact factor: 60.633

2.  Widespread 5-methylcytosine in the genomes of avian Coccidia and other apicomplexan parasites detected by an ELISA-based method.

Authors:  Zhenxing Gong; Hao Yin; Xueting Ma; Baohong Liu; Zhenglan Han; Lingqiao Gou; Jianping Cai
Journal:  Parasitol Res       Date:  2017-03-30       Impact factor: 2.289

3.  A map of 5-methylcytosine residues in Trypanosoma brucei tRNA revealed by sodium bisulfite sequencing.

Authors:  Kevin T Militello; Leanne M Chen; Sarah E Ackerman; Alexandra H Mandarano; Erika L Valentine
Journal:  Mol Biochem Parasitol       Date:  2014-01-02       Impact factor: 1.759

4.  Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes.

Authors:  Sam Alsford; David Horn
Journal:  Mol Cell Biol       Date:  2011-02-28       Impact factor: 4.272

5.  Conservation of Dcm-mediated cytosine DNA methylation in Escherichia coli.

Authors:  Kevin T Militello; Robert D Simon; Mehr Qureshi; Robert Maines; Michelle L VanHorne; Stacy M Hennick; Sangeeta K Jayakar; Sarah Pounder
Journal:  FEMS Microbiol Lett       Date:  2012-01-06       Impact factor: 2.742

Review 6.  Chromatin modifications, epigenetics, and how protozoan parasites regulate their lives.

Authors:  Matthew M Croken; Sheila C Nardelli; Kami Kim
Journal:  Trends Parasitol       Date:  2012-04-03

7.  Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei.

Authors:  Laura J Cliffe; T Nicolai Siegel; Marion Marshall; George A M Cross; Robert Sabatini
Journal:  Nucleic Acids Res       Date:  2010-03-09       Impact factor: 16.971

Review 8.  Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism.

Authors:  Fei Gao; Rui Wang; Mingyuan Liu
Journal:  Front Physiol       Date:  2014-01-10       Impact factor: 4.566

Review 9.  Epigenetic Regulation of Transcription in Trypanosomatid Protozoa.

Authors:  Santiago Martínez-Calvillo; Gabriela Romero-Meza; Juan C Vizuet-de-Rueda; Luis E Florencio-Martínez; Rebeca Manning-Cela; Tomás Nepomuceno-Mejía
Journal:  Curr Genomics       Date:  2018-02       Impact factor: 2.236

10.  A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination.

Authors:  Desislava P Staneva; Roberta Carloni; Tatsiana Auchynnikava; Pin Tong; Juri Rappsilber; A Arockia Jeyaprakash; Keith R Matthews; Robin C Allshire
Journal:  Genome Res       Date:  2021-08-18       Impact factor: 9.043
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