Literature DB >> 18789686

Synthesis and biological activity of anticoccidial agents: 5,6-diarylimidazo[2,1-b][1,3]thiazoles.

Andrew Scribner1, Susan Meitz, Michael Fisher, Matthew Wyvratt, Penny Leavitt, Paul Liberator, Anne Gurnett, Chris Brown, John Mathew, Donald Thompson, Dennis Schmatz, Tesfaye Biftu.   

Abstract

Novel 5,6-diarylimidazo[2,1-b][1,3]thiazoles bearing an amine substituent at the imidazothiazole 2-position have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 10.

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Year:  2008        PMID： 18789686     DOI： 10.1016/j.bmcl.2008.08.063

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  High Throughput Synthesis of 2,3,6-Trisubstituted-5,6-Dihydroimidazo[2,1-b]thiazole Derivatives.

Authors:  Yangmei Li; Marc Giulianotti; Richard A Houghten
Journal:  Tetrahedron Lett       Date:  2011-02-09       Impact factor: 2.415

2.  Microwave-assisted Hantzsch thiazole synthesis of N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines from the reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones and thioureas.

Authors:  Sukanta Kamila; Kimberly Mendoza; Edward R Biehl
Journal:  Tetrahedron Lett       Date:  2012-07-03       Impact factor: 2.415

3.  6-(4-Chloro-phen-yl)-3-methyl-imidazo[2,1-b]thia-zole.

Authors:  Alexander S Bunev; Elena V Sukhonosova; Vladimir E Statsyuk; Gennady I Ostapenko; Victor N Khrustalev
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-10-26
  3 in total

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