PURPOSE: To characterize patterns and determinants of normal and abnormal cognitive development in children with new onset epilepsy compared to healthy controls. METHODS: Longitudinal (2-year) cognitive growth was examined in 100 children, age 8-18 years, including healthy controls (n = 48) and children with new onset epilepsy (n = 52). Cognitive maturation was examined as a function of the presence/absence of two neurobehavioral comorbitiies (attention deficit hyperactivity disorder and/or academic problems) identified at the time of epilepsy diagnosis. Groups were compared across a comprehensive neuropsychological battery assessing intelligence, academic achievement, language, memory, executive function, and psychomotor speed. RESULTS: Children with new onset epilepsy without neurobehavioral comorbidities were comparable to healthy controls at baseline, rate of cognitive development, and follow-up assessment across all neuropsychological domains. In contrast, the presence of neurobehavioral comorbidities was associated with significantly worse baseline and prospective cognitive trajectories across all cognitive domains, especially executive functions. CONCLUSION: The presence of neurobehavioral comorbidities at the time of epilepsy onset is a major marker of abnormal cognitive development both prior to and after the onset of epilepsy.
PURPOSE: To characterize patterns and determinants of normal and abnormal cognitive development in children with new onset epilepsy compared to healthy controls. METHODS: Longitudinal (2-year) cognitive growth was examined in 100 children, age 8-18 years, including healthy controls (n = 48) and children with new onset epilepsy (n = 52). Cognitive maturation was examined as a function of the presence/absence of two neurobehavioral comorbitiies (attention deficit hyperactivity disorder and/or academic problems) identified at the time of epilepsy diagnosis. Groups were compared across a comprehensive neuropsychological battery assessing intelligence, academic achievement, language, memory, executive function, and psychomotor speed. RESULTS:Children with new onset epilepsy without neurobehavioral comorbidities were comparable to healthy controls at baseline, rate of cognitive development, and follow-up assessment across all neuropsychological domains. In contrast, the presence of neurobehavioral comorbidities was associated with significantly worse baseline and prospective cognitive trajectories across all cognitive domains, especially executive functions. CONCLUSION: The presence of neurobehavioral comorbidities at the time of epilepsy onset is a major marker of abnormal cognitive development both prior to and after the onset of epilepsy.
Authors: Anne Koponen; Ullamaija Seppälä; Kai Eriksson; Pirkko Nieminen; Antti Uutela; Matti Sillanpää; Leena Hyvärinen; Reetta Kälviäinen Journal: Epilepsia Date: 2007-03-13 Impact factor: 5.864
Authors: Angela M McNelis; David W Dunn; Cynthia S Johnson; Joan K Austin; Susan M Perkins Journal: Epilepsy Behav Date: 2007-02-12 Impact factor: 2.937
Authors: Jana E Jones; Ryann Watson; Raj Sheth; Rochelle Caplan; Monica Koehn; Michael Seidenberg; Bruce Hermann Journal: Dev Med Child Neurol Date: 2007-07 Impact factor: 5.449
Authors: Joseph Gonzalez-Heydrich; Alice Dodds; Jane Whitney; Carlene MacMillan; Deborah Waber; Stephen V Faraone; Katrina Boyer; Christine Mrakotsky; David DeMaso; Blaise Bourgeois; Joseph Biederman Journal: Epilepsy Behav Date: 2007-03-23 Impact factor: 2.937
Authors: Joy Parrish; Elizabeth Geary; Jana Jones; Raj Seth; Bruce Hermann; Michael Seidenberg Journal: Dev Med Child Neurol Date: 2007-06 Impact factor: 5.449
Authors: Anna W Byars; Ton J deGrauw; Cynthia S Johnson; Philip S Fastenau; Susan M Perkins; John C Egelhoff; Andrew Kalnin; David W Dunn; Joan K Austin Journal: Epilepsia Date: 2007-04-18 Impact factor: 5.864
Authors: Paul J Rathouz; Qianqian Zhao; Jana E Jones; Daren C Jackson; David A Hsu; Carl E Stafstrom; Michael Seidenberg; Bruce P Hermann Journal: Dev Med Child Neurol Date: 2014-03-21 Impact factor: 5.449
Authors: Rachel Friefeld Kesselmayer; Taylor McMillan; Beatrice Lee; Dace Almane; Bruce P Hermann; Jana E Jones Journal: Dev Med Child Neurol Date: 2020-01-27 Impact factor: 5.449
Authors: Elysa Widjaja; Jovanka Skocic; Cristina Go; O Carter Snead; Donald Mabbott; Mary Lou Smith Journal: Epilepsia Date: 2013-05-07 Impact factor: 5.864
Authors: Antonio Falace; Emmanuelle Buhler; Manuela Fadda; Françoise Watrin; Pellegrino Lippiello; Emilie Pallesi-Pocachard; Pietro Baldelli; Fabio Benfenati; Federico Zara; Alfonso Represa; Anna Fassio; Carlos Cardoso Journal: Proc Natl Acad Sci U S A Date: 2014-01-27 Impact factor: 11.205