Literature DB >> 18783277

A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.

Ian R Baxendale1, Steven V Ley, Christopher D Smith, Lucia Tamborini, Ana-Florina Voica.   

Abstract

A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent columns to effect bifurcation of the reaction pathway.

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Year:  2008        PMID： 18783277     DOI： 10.1021/cc800070a

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


  4 in total

1.  The flow synthesis of heterocycles for natural product and medicinal chemistry applications.

Authors:  Marcus Baumann; Ian R Baxendale; Steven V Ley
Journal:  Mol Divers       Date:  2010-10-20       Impact factor: 2.943

2.  An Automated Process for a Sequential Heterocycle/Multicomponent Reaction: Multistep Continuous Flow Synthesis of 5-(Thiazol-2-yl)-3,4-Dihydropyrimidin-2(1H)-ones.

Authors:  Nicholas Pagano; Ananda Herath; Nicholas D P Cosford
Journal:  J Flow Chem       Date:  2011-08-25       Impact factor: 2.786

3.  Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters.

Authors:  Alessandro Palmieri; Steven V Ley; Anastasios Polyzos; Mark Ladlow; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2009-05-20       Impact factor: 2.883

4.  The rapid generation of isothiocyanates in flow.

Authors:  Marcus Baumann; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2013-08-08       Impact factor: 2.883
  4 in total

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