Literature DB >> 18783214

Selective cytotoxic Ru(II) arene Cp* complex salts [R-PhRuCp*](+)X(-) for X = BF4(-), PF6(-), and BPh4(-).

Bradley T Loughrey1, Peter C Healy, Peter G Parsons, Michael L Williams.   

Abstract

A novel series of ionic Ru(II) arene Cp* sandwich complexes has been synthesized and characterized. Screening results for cytotoxicity against a range of human tumor cell lines and normal human cells indicate that the complexes show promising anticancer activity, which varies with changes in the arene ligand and the anionic counterion.

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Year:  2008        PMID： 18783214     DOI： 10.1021/ic801159f

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  9 in total

1.  Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos.

Authors:  Golara Golbaghi; Mohammad Mehdi Haghdoost; Debbie Yancu; Yossef López de Los Santos; Nicolas Doucet; Shunmoogum A Patten; J Thomas Sanderson; Annie Castonguay
Journal:  Organometallics       Date:  2019-01-31       Impact factor: 3.876

2.  Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos.

Authors:  Golara Golbaghi; Irène Pitard; Matthieu Lucas; Mohammad Mehdi Haghdoost; Yossef López de Los Santos; Nicolas Doucet; Shunmoogum A Patten; J Thomas Sanderson; Annie Castonguay
Journal:  Eur J Med Chem       Date:  2020-01-03       Impact factor: 6.514

3.  (η-Penta-methyl-cyclo-penta-dien-yl)(η-p-toluene-sulfonamide)ruthenium(II) tetra-phenyl-borate.

Authors:  Bradley T Loughrey; Michael L Williams; Sally-Ann Poulsen; Peter C Healy
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-11-20

4.  (η-Benzophenone)(η-penta-methyl-cyclo-penta-dien-yl)ruthenium(II) tetra-phenyl-borate.

Authors:  Bradley T Loughrey; Kevin Nadin; Michael L Williams; Peter C Healy
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-31

5.  (η-Penta-methyl-cyclo-penta-dien-yl)(η-toluene)-ruthenium(II) hexa-fluorido-phosphate.

Authors:  Wylie W N O; Alan J Lough; Robert H Morris
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-09-15

6.  Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase.

Authors:  Bradley T Loughrey; Michael L Williams; Peter C Healy; Alessio Innocenti; Daniela Vullo; Claudiu T Supuran; Peter G Parsons; Sally-Ann Poulsen
Journal:  J Biol Inorg Chem       Date:  2009-04-24       Impact factor: 3.358

7.  (η-Penta-methyl-cyclo-penta-dien-yl)(η-4-phenyl-butan-2-one)ruthenium(II) tetra-phenyl-borate.

Authors:  Bradley T Loughrey; Michael L Williams; Peter C Healy
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-11-13

8.  (η-Isopropyl N-phenyl-carbamate)(η-penta-methyl-cyclo-penta-dien-yl)ruthenium(II) tetra-phenyl-borate acetone monosolvate.

Authors:  Bradley T Loughrey; Michael L Williams; Peter C Healy
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-08-11

9.  New Triazolyl N^N Bidentate Rh(III), Ir(III), Ru(II) and Os(II) Complexes: Synthesis and Characterization, Probing Possible Relations between Cytotoxicity with Transfer Hydrogenation Efficacy and Interaction with Model Biomolecules.

Authors:  William K Chu; Charles K Rono; Banothile C E Makhubela
Journal:  Molecules       Date:  2022-03-23       Impact factor: 4.411
  9 in total

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