OBJECTIVE: Physical inactivity poses a major risk for obesity and chronic disease, and is influenced by both genetic and environmental factors. However, the genetic association between physical activity (PA) level and obesity is not well characterized. Our aims were to: (i) estimate the extent of additive genetic influences on physical activity while adjusting for household effects; and (ii) determine whether physical activity and adiposity measures share common genetic effects. SUBJECTS: The sample included 521 (42 % male) adult relatives, 18-86 years of age, from five large families in the Southwest Ohio Family Study. DESIGN: Sport, leisure and work PA were self-reported (Baecke Questionnaire of Habitual Physical Activity). Total body and trunk adiposity, including percentage body fat (%BF), were measured using dual-energy X-ray absorptiometry. Abdominal visceral and subcutaneous adipose tissue mass were measured using MRI. RESULTS: Heritabilities for adiposity and PA traits, and the genetic, household and environmental correlations among them, were estimated using maximum likelihood variance components methods. Significant genetic effects (P < 0.05) were found for sport (h2 = 0.26) and leisure PA (h2 = 0.17). Significant (P < 0.05) household effects existed for leisure PA (c2 = 0.25). Sport PA had a negative genetic correlation with central adiposity measurements adjusted for height (rhoG > |-0.40|). Sport and leisure PA had negative genetic correlations with %BF (rhoG > |-0.46|). CONCLUSIONS: The results suggest that the association of sport and leisure PA with lower adiposity is due, in part, to a common genetic inheritance of both reduced adiposity and the predisposition to engage in more physical activity.
OBJECTIVE: Physical inactivity poses a major risk for obesity and chronic disease, and is influenced by both genetic and environmental factors. However, the genetic association between physical activity (PA) level and obesity is not well characterized. Our aims were to: (i) estimate the extent of additive genetic influences on physical activity while adjusting for household effects; and (ii) determine whether physical activity and adiposity measures share common genetic effects. SUBJECTS: The sample included 521 (42 % male) adult relatives, 18-86 years of age, from five large families in the Southwest Ohio Family Study. DESIGN: Sport, leisure and work PA were self-reported (Baecke Questionnaire of Habitual Physical Activity). Total body and trunk adiposity, including percentage body fat (%BF), were measured using dual-energy X-ray absorptiometry. Abdominal visceral and subcutaneous adipose tissue mass were measured using MRI. RESULTS: Heritabilities for adiposity and PA traits, and the genetic, household and environmental correlations among them, were estimated using maximum likelihood variance components methods. Significant genetic effects (P < 0.05) were found for sport (h2 = 0.26) and leisure PA (h2 = 0.17). Significant (P < 0.05) household effects existed for leisure PA (c2 = 0.25). Sport PA had a negative genetic correlation with central adiposity measurements adjusted for height (rhoG > |-0.40|). Sport and leisure PA had negative genetic correlations with %BF (rhoG > |-0.46|). CONCLUSIONS: The results suggest that the association of sport and leisure PA with lower adiposity is due, in part, to a common genetic inheritance of both reduced adiposity and the predisposition to engage in more physical activity.
Authors: Riitta Simonen; Esko Levälahti; Jaakko Kaprio; Tapio Videman; Michele C Battié Journal: Med Sci Sports Exerc Date: 2004-09 Impact factor: 5.411
Authors: Audrey C Choh; Stefan A Czerwinski; Miryoung Lee; Ellen W Demerath; Alexander F Wilson; Bradford Towne; Roger M Siervogel Journal: Am J Hypertens Date: 2005-09 Impact factor: 2.689
Authors: R A Norman; D B Thompson; T Foroud; W T Garvey; P H Bennett; C Bogardus; E Ravussin Journal: Am J Hum Genet Date: 1997-01 Impact factor: 11.025
Authors: Riitta L Simonen; Tuomo Rankinen; Louis Pérusse; Arthur S Leon; James S Skinner; Jack H Wilmore; D C Rao; Claude Bouchard Journal: Physiol Behav Date: 2003-04
Authors: Ellen W Demerath; Nikki L Rogers; Derek Reed; Miryoung Lee; Audrey C Choh; Roger M Siervogel; Wm Cameron Chumlea; Bradford Towne; Stefan A Czerwinski Journal: Ann Hum Biol Date: 2010-12-22 Impact factor: 1.533
Authors: Tyler A Bosch; Lisa Chow; Donald R Dengel; Susan J Melhorn; Mary Webb; Danielle Yancey; Holly Callahan; Mary Rosalyn B De Leon; Vidhi Tyagi; Ellen A Schur Journal: Metabolism Date: 2015-06-06 Impact factor: 8.694
Authors: Pawan Noel; Krutika Patel; Chandra Durgampudi; Ram N Trivedi; Cristiane de Oliveira; Michael D Crowell; Rahul Pannala; Kenneth Lee; Randall Brand; Jennifer Chennat; Adam Slivka; Georgios I Papachristou; Asif Khalid; David C Whitcomb; James P DeLany; Rachel A Cline; Chathur Acharya; Deepthi Jaligama; Faris M Murad; Dhiraj Yadav; Sarah Navina; Vijay P Singh Journal: Gut Date: 2014-12-10 Impact factor: 23.059
Authors: Petra Majdak; Paula J Bucko; Ashley L Holloway; Tushar K Bhattacharya; Erin K DeYoung; Chessa N Kilby; Jonathan A Zombeck; Justin S Rhodes Journal: Behav Genet Date: 2014-08-10 Impact factor: 2.805
Authors: Jean Michel Rocha Sampaio Leite; Júlia Maria Pavan Soler; Andréa Roseli Vançan Russo Horimoto; Rafael O Alvim; Alexandre C Pereira Journal: Hum Hered Date: 2020-02-21 Impact factor: 0.444
Authors: Marcell D Cadney; Layla Hiramatsu; Zoe Thompson; Meng Zhao; Jarren C Kay; Jennifer M Singleton; Ralph Lacerda de Albuquerque; Margaret P Schmill; Wendy Saltzman; Theodore Garland Journal: Physiol Behav Date: 2021-03-16