Literature DB >> 18778099

Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa.

Kuan-Hon Lim1, Osamu Hiraku, Kanki Komiyama, Toh-Seok Kam.   

Abstract

Seven new indole alkaloids of the Aspidosperma type, jerantinines A-G (1-7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1-5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 microg/mL).

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Year:  2008        PMID： 18778099     DOI： 10.1021/np800435c

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

1.  Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules.

Authors:  Vijay J Raja; Kuan-Hon Lim; Chee-Onn Leong; Toh-Seok Kam; Tracey D Bradshaw
Journal:  Invest New Drugs       Date:  2014-06-15       Impact factor: 3.850

Review 2.  Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective.

Authors:  Jiaxing Wang; Duane D Miller; Wei Li
Journal:  Drug Discov Today       Date:  2021-12-08       Impact factor: 7.851

3.  Apoferritin-Encapsulated Jerantinine A for Transferrin Receptor Targeting and Enhanced Selectivity in Breast Cancer Therapy.

Authors:  Haneen Abuzaid; Salah Abdelrazig; Lenny Ferreira; Hilary M Collins; Dong-Hyun Kim; Kuan-Hon Lim; Toh-Seok Kam; Lyudmila Turyanska; Tracey D Bradshaw
Journal:  ACS Omega       Date:  2022-06-13

4.  Semi-syntheses and interrogation of indole-substituted Aspidosperma terpenoid alkaloids.

Authors:  Jinfeng Kang; Todd R Lewis; Alex Gardner; Rodrigo B Andrade; Rongsheng E Wang
Journal:  Org Biomol Chem       Date:  2022-05-18       Impact factor: 3.890

Review 5.  Synthesis of indole derivatives as prevalent moieties present in selected alkaloids.

Authors:  Majid M Heravi; Zahra Amiri; Kosar Kafshdarzadeh; Vahideh Zadsirjan
Journal:  RSC Adv       Date:  2021-10-15       Impact factor: 4.036

6.  Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in Catharanthus roseus.

Authors:  Inês Carqueijeiro; Stephanie Brown; Khoa Chung; Thu-Thuy Dang; Manish Walia; Sébastien Besseau; Thomas Dugé de Bernonville; Audrey Oudin; Arnaud Lanoue; Kevin Billet; Thibaut Munsch; Konstantinos Koudounas; Céline Melin; Charlotte Godon; Bienvenue Razafimandimby; Johan-Owen de Craene; Gaëlle Glévarec; Jillian Marc; Nathalie Giglioli-Guivarc'h; Marc Clastre; Benoit St-Pierre; Nicolas Papon; Rodrigo B Andrade; Sarah E O'Connor; Vincent Courdavault
Journal:  Plant Physiol       Date:  2018-06-22       Impact factor: 8.340

7.  Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1).

Authors:  Felicia Fei-Lei Chung; Perry Faith Tze Ming Tan; Vijay Joseph Raja; Boon-Shing Tan; Kuan-Hon Lim; Toh-Seok Kam; Ling-Wei Hii; Si Hoey Tan; Sze-Jia See; Yuen-Fen Tan; Li-Zhe Wong; Wai Keat Yam; Chun Wai Mai; Tracey D Bradshaw; Chee-Onn Leong
Journal:  Sci Rep       Date:  2017-02-15       Impact factor: 4.379

8.  The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun.

Authors:  Hayaa Moeed Alhuthali; Tracey D Bradshaw; Kuan-Hon Lim; Toh-Seok Kam; Claire H Seedhouse
Journal:  BMC Cancer       Date:  2020-07-07       Impact factor: 4.430

9.  Monoterpenoid indole alkaloids from Alstonia yunnanensis and their cytotoxic and anti-inflammatory activities.

Authors:  Peng Cao; Yong Liang; Xu Gao; Xiao-Ming Li; Zhen-Quan Song; Guobiao Liang
Journal:  Molecules       Date:  2012-11-16       Impact factor: 4.411

10.  Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

Authors:  Christopher J Smedley; Paul A Stanley; Mohannad E Qazzaz; Andrea E Prota; Natacha Olieric; Hilary Collins; Harry Eastman; Andrew S Barrow; Kuan-Hon Lim; Toh-Seok Kam; Brian J Smith; Hendrika M Duivenvoorden; Belinda S Parker; Tracey D Bradshaw; Michel O Steinmetz; John E Moses
Journal:  Sci Rep       Date:  2018-07-13       Impact factor: 4.379
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