Literature DB >> 18776911

Common variants of FUT2 are associated with plasma vitamin B12 levels.

Aditi Hazra1, Peter Kraft, Jacob Selhub, Edward L Giovannucci, Gilles Thomas, Robert N Hoover, Stephen J Chanock, David J Hunter.   

Abstract

We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels.

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Year:  2008        PMID： 18776911      PMCID： PMC2673801          DOI： 10.1038/ng.210

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

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