| Literature DB >> 18776534 |
Hisao Saneyoshi1, B Christie Vu, Stephen H Hughes, Paul L Boyer, Stefan G Sarafianos, Victor E Marquez.
Abstract
The conformationally locked carbocyclic nucleoside phosphonates 2 and 2' and key intermediates for the synthesis of 3 and 3' were prepared from a chiral cyclopentene derivative and epicholorohydrine, respectively. The structure of the nucleoside precursor 6 was confirmed by X-ray crystallography. These carbocyclic nucleoside phosphonates were designed to probe their binding interactions at the active site of HIV-1-RT.Entities:
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Year: 2008 PMID： 18776534 PMCID： PMC2727548 DOI： 10.1093/nass/nrn315
Source DB: PubMed Journal: Nucleic Acids Symp Ser (Oxf) ISSN： 0261-3166