Literature DB >> 17168730

Synthesis and biological activity of phosphonated nucleosides: part 1. Furanose, carbocyclic and heterocyclic analogues.

Anna Piperno1, Maria A Chiacchio, Daniela Iannazzo, Roberto Romeo.   

Abstract

Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review.

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Year:  2006        PMID： 17168730     DOI： 10.2174/092986706779026110

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  4 in total

1.  Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT.

Authors:  Hisao Saneyoshi; B Christie Vu; Stephen H Hughes; Paul L Boyer; Stefan G Sarafianos; Victor E Marquez
Journal:  Nucleic Acids Symp Ser (Oxf)       Date:  2008

2.  C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation.

Authors:  Roberto Romeo; Caterina Carnovale; Salvatore V Giofrè; Maria A Chiacchio; Adriana Garozzo; Emanuele Amata; Giovanni Romeo; Ugo Chiacchio
Journal:  Beilstein J Org Chem       Date:  2015-03-09       Impact factor: 2.883

3.  Syntheses of isoxazoline-carbocyclic nucleosides and their antiviral evaluation: a standard protocol.

Authors:  Paolo Quadrelli; Naiara Vazquez Martinez; Roberto Scrocchi; Antonino Corsaro; Venerando Pistarà
Journal:  ScientificWorldJournal       Date:  2014-10-30

4.  Synthesis of azanucleosides through regioselective ring-opening of epoxides catalyzed by sulphated zirconia under microwave and solvent-free conditions.

Authors:  Celia Xochitl Hernández-Reyes; Deyanira Angeles-Beltrán; Leticia Lomas-Romero; Eduardo González-Zamora; Rubén Gaviño; Jorge Cárdenas; José Antonio Morales-Serna; Guillermo E Negrón-Silva
Journal:  Molecules       Date:  2012-03-15       Impact factor: 4.411
  4 in total

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