Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Nested genes and increasing organizational complexity of metazoan genomes.

Literature DB >> 18774620

Nested genes and increasing organizational complexity of metazoan genomes.

Raquel Assis¹, Alexey S Kondrashov, Eugene V Koonin, Fyodor A Kondrashov.

Abstract

The most common form of protein-coding gene overlap in eukaryotes is a simple nested structure, whereby one gene is embedded in an intron of another. Analysis of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed substantially higher rates of evolutionary gains than losses. The accumulation of nested gene structures could not be attributed to any obvious functional relationships between the genes involved and represents an increase of the organizational complexity of animal genomes via a neutral process.

Entities: Disease Gene Species

Mesh：

Year: 2008 PMID： 18774620 PMCID： PMC3380635 DOI： 10.1016/j.tig.2008.08.003

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

24 in total

1. Intron evolution as a population-genetic process.

Authors: Michael Lynch
Journal: Proc Natl Acad Sci U S A Date: 2002-04-30 Impact factor: 11.205

Review 2. Small regulatory RNAs in mammals.

Authors: John S Mattick; Igor V Makunin
Journal: Hum Mol Genet Date: 2005-04-15 Impact factor: 6.150

3. Nested genes in the human genome.

Authors: Peng Yu; Dalong Ma; Mingxu Xu
Journal: Genomics Date: 2005-10 Impact factor: 5.736

4. The frailty of adaptive hypotheses for the origins of organismal complexity.

Authors: Michael Lynch
Journal: Proc Natl Acad Sci U S A Date: 2007-05-09 Impact factor: 11.205

Review 5. Genome-wide transcription and the implications for genomic organization.

Authors: Philipp Kapranov; Aarron T Willingham; Thomas R Gingeras
Journal: Nat Rev Genet Date: 2007-05-08 Impact factor: 53.242

6. Transcriptional landscape of the human and fly genomes: nonlinear and multifunctional modular model of transcriptomes.

Authors: A T Willingham; S Dike; J Cheng; J R Manak; I Bell; E Cheung; J Drenkow; E Dumais; R Duttagupta; M Ganesh; S Ghosh; G Helt; D Nix; A Piccolboni; V Sementchenko; H Tammana; P Kapranov; T R Gingeras
Journal: Cold Spring Harb Symp Quant Biol Date: 2006

7. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.

Authors: Ewan Birney; John A Stamatoyannopoulos; Anindya Dutta; Roderic Guigó; Thomas R Gingeras; Elliott H Margulies; Zhiping Weng; Michael Snyder; Emmanouil T Dermitzakis; Robert E Thurman; Michael S Kuehn; Christopher M Taylor; Shane Neph; Christoph M Koch; Saurabh Asthana; Ankit Malhotra; Ivan Adzhubei; Jason A Greenbaum; Robert M Andrews; Paul Flicek; Patrick J Boyle; Hua Cao; Nigel P Carter; Gayle K Clelland; Sean Davis; Nathan Day; Pawandeep Dhami; Shane C Dillon; Michael O Dorschner; Heike Fiegler; Paul G Giresi; Jeff Goldy; Michael Hawrylycz; Andrew Haydock; Richard Humbert; Keith D James; Brett E Johnson; Ericka M Johnson; Tristan T Frum; Elizabeth R Rosenzweig; Neerja Karnani; Kirsten Lee; Gregory C Lefebvre; Patrick A Navas; Fidencio Neri; Stephen C J Parker; Peter J Sabo; Richard Sandstrom; Anthony Shafer; David Vetrie; Molly Weaver; Sarah Wilcox; Man Yu; Francis S Collins; Job Dekker; Jason D Lieb; Thomas D Tullius; Gregory E Crawford; Shamil Sunyaev; William S Noble; Ian Dunham; France Denoeud; Alexandre Reymond; Philipp Kapranov; Joel Rozowsky; Deyou Zheng; Robert Castelo; Adam Frankish; Jennifer Harrow; Srinka Ghosh; Albin Sandelin; Ivo L Hofacker; Robert Baertsch; Damian Keefe; Sujit Dike; Jill Cheng; Heather A Hirsch; Edward A Sekinger; Julien Lagarde; Josep F Abril; Atif Shahab; Christoph Flamm; Claudia Fried; Jörg Hackermüller; Jana Hertel; Manja Lindemeyer; Kristin Missal; Andrea Tanzer; Stefan Washietl; Jan Korbel; Olof Emanuelsson; Jakob S Pedersen; Nancy Holroyd; Ruth Taylor; David Swarbreck; Nicholas Matthews; Mark C Dickson; Daryl J Thomas; Matthew T Weirauch; James Gilbert; Jorg Drenkow; Ian Bell; XiaoDong Zhao; K G Srinivasan; Wing-Kin Sung; Hong Sain Ooi; Kuo Ping Chiu; Sylvain Foissac; Tyler Alioto; Michael Brent; Lior Pachter; Michael L Tress; Alfonso Valencia; Siew Woh Choo; Chiou Yu Choo; Catherine Ucla; Caroline Manzano; Carine Wyss; Evelyn Cheung; Taane G Clark; James B Brown; Madhavan Ganesh; Sandeep Patel; Hari Tammana; Jacqueline Chrast; Charlotte N Henrichsen; Chikatoshi Kai; Jun Kawai; Ugrappa Nagalakshmi; Jiaqian Wu; Zheng Lian; Jin Lian; Peter Newburger; Xueqing Zhang; Peter Bickel; John S Mattick; Piero Carninci; Yoshihide Hayashizaki; Sherman Weissman; Tim Hubbard; Richard M Myers; Jane Rogers; Peter F Stadler; Todd M Lowe; Chia-Lin Wei; Yijun Ruan; Kevin Struhl; Mark Gerstein; Stylianos E Antonarakis; Yutao Fu; Eric D Green; Ulaş Karaöz; Adam Siepel; James Taylor; Laura A Liefer; Kris A Wetterstrand; Peter J Good; Elise A Feingold; Mark S Guyer; Gregory M Cooper; George Asimenos; Colin N Dewey; Minmei Hou; Sergey Nikolaev; Juan I Montoya-Burgos; Ari Löytynoja; Simon Whelan; Fabio Pardi; Tim Massingham; Haiyan Huang; Nancy R Zhang; Ian Holmes; James C Mullikin; Abel Ureta-Vidal; Benedict Paten; Michael Seringhaus; Deanna Church; Kate Rosenbloom; W James Kent; Eric A Stone; Serafim Batzoglou; Nick Goldman; Ross C Hardison; David Haussler; Webb Miller; Arend Sidow; Nathan D Trinklein; Zhengdong D Zhang; Leah Barrera; Rhona Stuart; David C King; Adam Ameur; Stefan Enroth; Mark C Bieda; Jonghwan Kim; Akshay A Bhinge; Nan Jiang; Jun Liu; Fei Yao; Vinsensius B Vega; Charlie W H Lee; Patrick Ng; Atif Shahab; Annie Yang; Zarmik Moqtaderi; Zhou Zhu; Xiaoqin Xu; Sharon Squazzo; Matthew J Oberley; David Inman; Michael A Singer; Todd A Richmond; Kyle J Munn; Alvaro Rada-Iglesias; Ola Wallerman; Jan Komorowski; Joanna C Fowler; Phillippe Couttet; Alexander W Bruce; Oliver M Dovey; Peter D Ellis; Cordelia F Langford; David A Nix; Ghia Euskirchen; Stephen Hartman; Alexander E Urban; Peter Kraus; Sara Van Calcar; Nate Heintzman; Tae Hoon Kim; Kun Wang; Chunxu Qu; Gary Hon; Rosa Luna; Christopher K Glass; M Geoff Rosenfeld; Shelley Force Aldred; Sara J Cooper; Anason Halees; Jane M Lin; Hennady P Shulha; Xiaoling Zhang; Mousheng Xu; Jaafar N S Haidar; Yong Yu; Yijun Ruan; Vishwanath R Iyer; Roland D Green; Claes Wadelius; Peggy J Farnham; Bing Ren; Rachel A Harte; Angie S Hinrichs; Heather Trumbower; Hiram Clawson; Jennifer Hillman-Jackson; Ann S Zweig; Kayla Smith; Archana Thakkapallayil; Galt Barber; Robert M Kuhn; Donna Karolchik; Lluis Armengol; Christine P Bird; Paul I W de Bakker; Andrew D Kern; Nuria Lopez-Bigas; Joel D Martin; Barbara E Stranger; Abigail Woodroffe; Eugene Davydov; Antigone Dimas; Eduardo Eyras; Ingileif B Hallgrímsdóttir; Julian Huppert; Michael C Zody; Gonçalo R Abecasis; Xavier Estivill; Gerard G Bouffard; Xiaobin Guan; Nancy F Hansen; Jacquelyn R Idol; Valerie V B Maduro; Baishali Maskeri; Jennifer C McDowell; Morgan Park; Pamela J Thomas; Alice C Young; Robert W Blakesley; Donna M Muzny; Erica Sodergren; David A Wheeler; Kim C Worley; Huaiyang Jiang; George M Weinstock; Richard A Gibbs; Tina Graves; Robert Fulton; Elaine R Mardis; Richard K Wilson; Michele Clamp; James Cuff; Sante Gnerre; David B Jaffe; Jean L Chang; Kerstin Lindblad-Toh; Eric S Lander; Maxim Koriabine; Mikhail Nefedov; Kazutoyo Osoegawa; Yuko Yoshinaga; Baoli Zhu; Pieter J de Jong
Journal: Nature Date: 2007-06-14 Impact factor: 49.962

8. Conserved arrangement of nested genes at the Drosophila Gart locus.

Authors: S Henikoff; M K Eghtedarzadeh
Journal: Genetics Date: 1987-12 Impact factor: 4.562

9. Collision events between RNA polymerases in convergent transcription studied by atomic force microscopy.

Authors: Neal Crampton; William A Bonass; Jennifer Kirkham; Claudio Rivetti; Neil H Thomson
Journal: Nucleic Acids Res Date: 2006-09-29 Impact factor: 16.971

10. Evolution of genes and genomes on the Drosophila phylogeny.

Authors: Andrew G Clark; Michael B Eisen; Douglas R Smith; Casey M Bergman; Brian Oliver; Therese A Markow; Thomas C Kaufman; Manolis Kellis; William Gelbart; Venky N Iyer; Daniel A Pollard; Timothy B Sackton; Amanda M Larracuente; Nadia D Singh; Jose P Abad; Dawn N Abt; Boris Adryan; Montserrat Aguade; Hiroshi Akashi; Wyatt W Anderson; Charles F Aquadro; David H Ardell; Roman Arguello; Carlo G Artieri; Daniel A Barbash; Daniel Barker; Paolo Barsanti; Phil Batterham; Serafim Batzoglou; Dave Begun; Arjun Bhutkar; Enrico Blanco; Stephanie A Bosak; Robert K Bradley; Adrianne D Brand; Michael R Brent; Angela N Brooks; Randall H Brown; Roger K Butlin; Corrado Caggese; Brian R Calvi; A Bernardo de Carvalho; Anat Caspi; Sergio Castrezana; Susan E Celniker; Jean L Chang; Charles Chapple; Sourav Chatterji; Asif Chinwalla; Alberto Civetta; Sandra W Clifton; Josep M Comeron; James C Costello; Jerry A Coyne; Jennifer Daub; Robert G David; Arthur L Delcher; Kim Delehaunty; Chuong B Do; Heather Ebling; Kevin Edwards; Thomas Eickbush; Jay D Evans; Alan Filipski; Sven Findeiss; Eva Freyhult; Lucinda Fulton; Robert Fulton; Ana C L Garcia; Anastasia Gardiner; David A Garfield; Barry E Garvin; Greg Gibson; Don Gilbert; Sante Gnerre; Jennifer Godfrey; Robert Good; Valer Gotea; Brenton Gravely; Anthony J Greenberg; Sam Griffiths-Jones; Samuel Gross; Roderic Guigo; Erik A Gustafson; Wilfried Haerty; Matthew W Hahn; Daniel L Halligan; Aaron L Halpern; Gillian M Halter; Mira V Han; Andreas Heger; LaDeana Hillier; Angie S Hinrichs; Ian Holmes; Roger A Hoskins; Melissa J Hubisz; Dan Hultmark; Melanie A Huntley; David B Jaffe; Santosh Jagadeeshan; William R Jeck; Justin Johnson; Corbin D Jones; William C Jordan; Gary H Karpen; Eiko Kataoka; Peter D Keightley; Pouya Kheradpour; Ewen F Kirkness; Leonardo B Koerich; Karsten Kristiansen; Dave Kudrna; Rob J Kulathinal; Sudhir Kumar; Roberta Kwok; Eric Lander; Charles H Langley; Richard Lapoint; Brian P Lazzaro; So-Jeong Lee; Lisa Levesque; Ruiqiang Li; Chiao-Feng Lin; Michael F Lin; Kerstin Lindblad-Toh; Ana Llopart; Manyuan Long; Lloyd Low; Elena Lozovsky; Jian Lu; Meizhong Luo; Carlos A Machado; Wojciech Makalowski; Mar Marzo; Muneo Matsuda; Luciano Matzkin; Bryant McAllister; Carolyn S McBride; Brendan McKernan; Kevin McKernan; Maria Mendez-Lago; Patrick Minx; Michael U Mollenhauer; Kristi Montooth; Stephen M Mount; Xu Mu; Eugene Myers; Barbara Negre; Stuart Newfeld; Rasmus Nielsen; Mohamed A F Noor; Patrick O'Grady; Lior Pachter; Montserrat Papaceit; Matthew J Parisi; Michael Parisi; Leopold Parts; Jakob S Pedersen; Graziano Pesole; Adam M Phillippy; Chris P Ponting; Mihai Pop; Damiano Porcelli; Jeffrey R Powell; Sonja Prohaska; Kim Pruitt; Marta Puig; Hadi Quesneville; Kristipati Ravi Ram; David Rand; Matthew D Rasmussen; Laura K Reed; Robert Reenan; Amy Reily; Karin A Remington; Tania T Rieger; Michael G Ritchie; Charles Robin; Yu-Hui Rogers; Claudia Rohde; Julio Rozas; Marc J Rubenfield; Alfredo Ruiz; Susan Russo; Steven L Salzberg; Alejandro Sanchez-Gracia; David J Saranga; Hajime Sato; Stephen W Schaeffer; Michael C Schatz; Todd Schlenke; Russell Schwartz; Carmen Segarra; Rama S Singh; Laura Sirot; Marina Sirota; Nicholas B Sisneros; Chris D Smith; Temple F Smith; John Spieth; Deborah E Stage; Alexander Stark; Wolfgang Stephan; Robert L Strausberg; Sebastian Strempel; David Sturgill; Granger Sutton; Granger G Sutton; Wei Tao; Sarah Teichmann; Yoshiko N Tobari; Yoshihiko Tomimura; Jason M Tsolas; Vera L S Valente; Eli Venter; J Craig Venter; Saverio Vicario; Filipe G Vieira; Albert J Vilella; Alfredo Villasante; Brian Walenz; Jun Wang; Marvin Wasserman; Thomas Watts; Derek Wilson; Richard K Wilson; Rod A Wing; Mariana F Wolfner; Alex Wong; Gane Ka-Shu Wong; Chung-I Wu; Gabriel Wu; Daisuke Yamamoto; Hsiao-Pei Yang; Shiaw-Pyng Yang; James A Yorke; Kiyohito Yoshida; Evgeny Zdobnov; Peili Zhang; Yu Zhang; Aleksey V Zimin; Jennifer Baldwin; Amr Abdouelleil; Jamal Abdulkadir; Adal Abebe; Brikti Abera; Justin Abreu; St Christophe Acer; Lynne Aftuck; Allen Alexander; Peter An; Erica Anderson; Scott Anderson; Harindra Arachi; Marc Azer; Pasang Bachantsang; Andrew Barry; Tashi Bayul; Aaron Berlin; Daniel Bessette; Toby Bloom; Jason Blye; Leonid Boguslavskiy; Claude Bonnet; Boris Boukhgalter; Imane Bourzgui; Adam Brown; Patrick Cahill; Sheridon Channer; Yama Cheshatsang; Lisa Chuda; Mieke Citroen; Alville Collymore; Patrick Cooke; Maura Costello; Katie D'Aco; Riza Daza; Georgius De Haan; Stuart DeGray; Christina DeMaso; Norbu Dhargay; Kimberly Dooley; Erin Dooley; Missole Doricent; Passang Dorje; Kunsang Dorjee; Alan Dupes; Richard Elong; Jill Falk; Abderrahim Farina; Susan Faro; Diallo Ferguson; Sheila Fisher; Chelsea D Foley; Alicia Franke; Dennis Friedrich; Loryn Gadbois; Gary Gearin; Christina R Gearin; Georgia Giannoukos; Tina Goode; Joseph Graham; Edward Grandbois; Sharleen Grewal; Kunsang Gyaltsen; Nabil Hafez; Birhane Hagos; Jennifer Hall; Charlotte Henson; Andrew Hollinger; Tracey Honan; Monika D Huard; Leanne Hughes; Brian Hurhula; M Erii Husby; Asha Kamat; Ben Kanga; Seva Kashin; Dmitry Khazanovich; Peter Kisner; Krista Lance; Marcia Lara; William Lee; Niall Lennon; Frances Letendre; Rosie LeVine; Alex Lipovsky; Xiaohong Liu; Jinlei Liu; Shangtao Liu; Tashi Lokyitsang; Yeshi Lokyitsang; Rakela Lubonja; Annie Lui; Pen MacDonald; Vasilia Magnisalis; Kebede Maru; Charles Matthews; William McCusker; Susan McDonough; Teena Mehta; James Meldrim; Louis Meneus; Oana Mihai; Atanas Mihalev; Tanya Mihova; Rachel Mittelman; Valentine Mlenga; Anna Montmayeur; Leonidas Mulrain; Adam Navidi; Jerome Naylor; Tamrat Negash; Thu Nguyen; Nga Nguyen; Robert Nicol; Choe Norbu; Nyima Norbu; Nathaniel Novod; Barry O'Neill; Sahal Osman; Eva Markiewicz; Otero L Oyono; Christopher Patti; Pema Phunkhang; Fritz Pierre; Margaret Priest; Sujaa Raghuraman; Filip Rege; Rebecca Reyes; Cecil Rise; Peter Rogov; Keenan Ross; Elizabeth Ryan; Sampath Settipalli; Terry Shea; Ngawang Sherpa; Lu Shi; Diana Shih; Todd Sparrow; Jessica Spaulding; John Stalker; Nicole Stange-Thomann; Sharon Stavropoulos; Catherine Stone; Christopher Strader; Senait Tesfaye; Talene Thomson; Yama Thoulutsang; Dawa Thoulutsang; Kerri Topham; Ira Topping; Tsamla Tsamla; Helen Vassiliev; Andy Vo; Tsering Wangchuk; Tsering Wangdi; Michael Weiand; Jane Wilkinson; Adam Wilson; Shailendra Yadav; Geneva Young; Qing Yu; Lisa Zembek; Danni Zhong; Andrew Zimmer; Zac Zwirko; David B Jaffe; Pablo Alvarez; Will Brockman; Jonathan Butler; CheeWhye Chin; Sante Gnerre; Manfred Grabherr; Michael Kleber; Evan Mauceli; Iain MacCallum
Journal: Nature Date: 2007-11-08 Impact factor: 49.962

24 in total

Review 1. An overview of nested genes in eukaryotic genomes.

Authors: Anuj Kumar
Journal: Eukaryot Cell Date: 2009-06-19

Review 2. Origin of the fittest: link between emergent variation and evolutionary change as a critical question in evolutionary biology.

Authors: Alexander V Badyaev
Journal: Proc Biol Sci Date: 2011-04-13 Impact factor: 5.349

3. Origin of spliceosomal introns and alternative splicing.

Authors: Manuel Irimia; Scott William Roy
Journal: Cold Spring Harb Perspect Biol Date: 2014-06-02 Impact factor: 10.005

Review 4. Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest.

Authors: James D Smith; Maria H Meehan; John Crean; Amanda McCann
Journal: Cell Mol Life Sci Date: 2011-05-20 Impact factor: 9.261

5. Hitting two birds with one stone: The unforeseen consequences of nested gene knockouts in Caenorhabditis elegans.

Authors: Richard Jovelin; Asher D Cutter
Journal: Worm Date: 2016-04-06

6. Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in Drosophila.

Authors: Oriol Calvete; Josefa González; Esther Betrán; Alfredo Ruiz
Journal: Mol Biol Evol Date: 2012-02-10 Impact factor: 16.240

Review 7. Origin and evolution of spliceosomal introns.

Authors: Igor B Rogozin; Liran Carmel; Miklos Csuros; Eugene V Koonin
Journal: Biol Direct Date: 2012-04-16 Impact factor: 4.540

8. Family size and turnover rates among several classes of small non-protein-coding RNA genes in Caenorhabditis nematodes.

Authors: Paul Po-Shen Wang; Ilya Ruvinsky
Journal: Genome Biol Evol Date: 2012-03-30 Impact factor: 3.416

Review 9. Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism.

Authors: R A Clarke; S Lee; V Eapen
Journal: Transl Psychiatry Date: 2012-09-04 Impact factor: 6.222

10. Overlapping genes of Aedes aegypti: evolutionary implications from comparison with orthologs of Anopheles gambiae and other insects.

Authors: Susanta K Behura; David W Severson
Journal: BMC Evol Biol Date: 2013-06-18 Impact factor: 3.260