Literature DB >> 18773917

Induction of mucosal immunity in the avian Harderian gland with a replication-deficient Ad5 vector expressing avian influenza H5 hemagglutinin.

Frederik W van Ginkel1, De-chu C Tang, Stephen L Gulley, Haroldo Toro.   

Abstract

The chicken Harderian gland (HG) plays an important role in adaptive immune responses upon ocular exposure to avian pathogens such as avian influenza (AI). To determine the role of HGs in generating immunity, chickens were immunized ocularly with an adenovirus (Ad5) vector expressing the AI hemagglutinin H5 gene. The Ad5-H5 vector induced H5 transgene expression and induced H5- and Ad5-specific IgA and IgG spot-forming cells (SFCs) in the HGs. The IgA and IgG SFC peaked on day 9 forAd5 and day 11 for the H5 protein. In addition, Ad5- and H5-specific antibodies were induced in serum. IgA in chicken tears was predominantly dimeric, while in serum monomeric IgA was most abundant. Analysis of HG mRNA confirmed expression of the polymeric immunoglobulin receptor (plgR). These data demonstrated the importance of HGs to generate mucosal and systemic immunity to AI following ocular Ad5-H5 administration to chickens.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 18773917      PMCID： PMC2931278          DOI： 10.1016/j.dci.2008.07.018

Source DB:  PubMed          Journal:  Dev Comp Immunol        ISSN： 0145-305X            Impact factor:   3.636


  30 in total

1.  Eye-drop DNA can induce IgA in the tears and bile of chickens.

Authors:  P H Russell; A Mackie
Journal:  Vet Immunol Immunopathol       Date:  2001-08-10       Impact factor: 2.046

2.  Possible route of antigen uptake by the Harderian gland of the domestic fowl.

Authors:  R B Burns
Journal:  Br Poult Sci       Date:  1977-07       Impact factor: 2.095

3.  Peculiar secretory IgA system identified in chickens.

Authors:  H Watanabe; K Kobayashi
Journal:  J Immunol       Date:  1974-11       Impact factor: 5.422

4.  Studies on subunit components of chicken polymeric immunoglobulins.

Authors:  K Kobayashi; H Hirai
Journal:  J Immunol       Date:  1980-04       Impact factor: 5.422

5.  A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells.

Authors:  C C Czerkinsky; L A Nilsson; H Nygren; O Ouchterlony; A Tarkowski
Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

6.  Cloning and expression of the chicken immunoglobulin joining (J)-chain cDNA.

Authors:  T Takahashi; T Iwase; T Tachibana; K Komiyama; K Kobayashi; C L Chen; J Mestecky; I Moro
Journal:  Immunogenetics       Date:  2000-02       Impact factor: 2.846

7.  Peculiar secretory IgA system identified in chickens. II. Identification and distribution of free secretory component and immunoglobulins of IgA, IgM, and IgG in chicken external secretions.

Authors:  H Watanabe; K Kobayashi; Y Isayama
Journal:  J Immunol       Date:  1975-10       Impact factor: 5.422

8.  Protection of chickens against avian influenza with non-replicating adenovirus-vectored vaccine.

Authors:  Haroldo Toro; De-chu C Tang; David L Suarez; Jianfeng Zhang; Zhongkai Shi
Journal:  Vaccine       Date:  2008-03-17       Impact factor: 3.641

9.  A functional polymeric immunoglobulin receptor in chicken (Gallus gallus) indicates ancient role of secretory IgA in mucosal immunity.

Authors:  Willemien H Wieland; Diego Orzáez; Aart Lammers; Henk K Parmentier; Martin W A Verstegen; Arjen Schots
Journal:  Biochem J       Date:  2004-06-15       Impact factor: 3.857

10.  Specific antibody secreting cells from chickens can be detected by three days and memory B cells by three weeks post-infection with the avian respiratory coronavirus.

Authors:  Jianwu Pei; Ellen W Collisson
Journal:  Dev Comp Immunol       Date:  2005       Impact factor: 3.636
View more
  5 in total

1.  Avian influenza vaccination in chickens and pigs with replication-competent adenovirus-free human recombinant adenovirus 5.

Authors:  Haroldo Toro; Frederik W van Ginkel; De-Chu C Tang; Bettina Schemera; Soren Rodning; Joseph Newton
Journal:  Avian Dis       Date:  2010-03       Impact factor: 1.577

Review 2.  Adenovirus as a carrier for the development of influenza virus-free avian influenza vaccines.

Authors:  De-chu C Tang; Jianfeng Zhang; Haroldo Toro; Zhongkai Shi; Kent R Van Kampen
Journal:  Expert Rev Vaccines       Date:  2009-04       Impact factor: 5.217

3.  Effect of passive immunization on immunogenicity and protective efficacy of vaccination against a Mexican low-pathogenic avian H5N2 influenza virus.

Authors:  Heather L Forrest; Alejandro Garcia; Angela Danner; Jon P Seiler; Kimberly Friedman; Robert G Webster; Jeremy C Jones
Journal:  Influenza Other Respir Viruses       Date:  2013-07-25       Impact factor: 4.380

4.  Immune Responses in the Eye-Associated Lymphoid Tissues of Chickens after Ocular Inoculation with Vaccine and Virulent Strains of the Respiratory Infectious Laryngotracheitis Virus (ILTV).

Authors:  Gabriela Beltrán; David J Hurley; Robert M Gogal; Shayan Sharif; Leah R Read; Susan M Williams; Carmen F Jerry; Daniel A Maekawa; Maricarmen García
Journal:  Viruses       Date:  2019-07-10       Impact factor: 5.048

5.  Age-dependent immune responses and immune protection after avian coronavirus vaccination.

Authors:  Frederik W van Ginkel; Justin Padgett; Gisela Martinez-Romero; Matthew S Miller; Kellye S Joiner; Stephen L Gulley
Journal:  Vaccine       Date:  2015-04-21       Impact factor: 3.641
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.