| Literature DB >> 187722 |
Abstract
An investigation of the activity of nuclear RNA polymerase following infection of LS cells with HSV-1 shows a decline in both major activities. This effect is not entirely due to inhibition of cellular protein synthesis, and the effect of alpha-amanitin-sensitive RNA polymerase is mediated by a protein(s) synthesized in the infected cell. Changes in the properties of this RNA polymerase activity include a reduction in the relative UTP/GTP incorporation ratio and an increased sensitivity to inhibition by actinomycin D, indicating that RNA polymerase II is involved in virus transcription.Entities:
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Year: 1976 PMID： 187722 DOI： 10.1099/0022-1317-33-3-471
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891