Literature DB >> 18772021

Analysis of low molecular weight GTPase activity in endothelial cell cultures.

Erika S Wittchen1, Keith Burridge.   

Abstract

GTPases control a myriad of cellular processes, including cell migration, proliferation, polarity, and cell adhesion, which includes cell-cell junction regulation. Angiogenesis requires many of these diverse cellular events to occur appropriately. In this chapter, we describe the techniques for in vitro assessment of GTPase activity in endothelial cells grown in monolayer culture as a model system for studying their role during angiogenesis.

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Year:  2008        PMID： 18772021     DOI： 10.1016/S0076-6879(08)02014-4

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  12 in total

1.  Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42.

Authors:  Gina L Razidlo; Kevin M Burton; Mark A McNiven
Journal:  J Biol Chem       Date:  2018-05-31       Impact factor: 5.157

2.  The small GTPase Rap1 is a novel regulator of RPE cell barrier function.

Authors:  Erika S Wittchen; M Elizabeth Hartnett
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-09-27       Impact factor: 4.799

3.  Using magnets and magnetic beads to dissect signaling pathways activated by mechanical tension applied to cells.

Authors:  R J Marjoram; C Guilluy; K Burridge
Journal:  Methods       Date:  2015-09-30       Impact factor: 3.608

4.  Rapid parallel flow cytometry assays of active GTPases using effector beads.

Authors:  Tione Buranda; Soumik BasuRay; Scarlett Swanson; Jacob Agola; Virginie Bondu; Angela Wandinger-Ness
Journal:  Anal Biochem       Date:  2013-08-06       Impact factor: 3.365

5.  Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers.

Authors:  Campbell D Lawson; Cheng Fan; Natalia Mitin; Nicole M Baker; Samuel D George; David M Graham; Charles M Perou; Keith Burridge; Channing J Der; Kent L Rossman
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6.  The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation.

Authors:  Jos van Rijssel; Jeffrey Kroon; Mark Hoogenboezem; Floris P J van Alphen; Renske J de Jong; Elena Kostadinova; Dirk Geerts; Peter L Hordijk; Jaap D van Buul
Journal:  Mol Biol Cell       Date:  2012-06-13       Impact factor: 4.138

7.  The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2.

Authors:  Megan E Arrington; Brenda Temple; Antje Schaefer; Sharon L Campbell
Journal:  J Biol Chem       Date:  2020-07-07       Impact factor: 5.486

8.  Viral activation of MK2-hsp27-p115RhoGEF-RhoA signaling axis causes cytoskeletal rearrangements, p-body disruption and ARE-mRNA stabilization.

Authors:  Jennifer A Corcoran; Benjamin P Johnston; Craig McCormick
Journal:  PLoS Pathog       Date:  2015-01-08       Impact factor: 6.823

9.  Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif.

Authors:  Amir Aghajanian; Erika S Wittchen; Sharon L Campbell; Keith Burridge
Journal:  PLoS One       Date:  2009-11-26       Impact factor: 3.240

10.  The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2.

Authors:  Jos Van Rijssel; Ilse Timmerman; Floris P J Van Alphen; Mark Hoogenboezem; Olexandr Korchynskyi; Dirk Geerts; Judy Geissler; Kris A Reedquist; Hans W M Niessen; Jaap D Van Buul
Journal:  Biol Open       Date:  2013-04-16       Impact factor: 2.422
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