OBJECTIVES: To prospectively relate C-reactive protein (CRP), a systemic marker of inflammation, to cognitive change over a 1-year follow-up period. DESIGN: Prospective 1-year follow-up. SETTING: Outpatient university medical setting. PARTICIPANTS: Seventy-eight adults (aged 56-84; 39% female) with cardiovascular disease. MEASUREMENTS: CRP levels were measured using a high-sensitivity assay, and participants completed a neuropsychological battery at study entry. Neuropsychological assessment was repeated 1 year later. RESULTS: The association between CRP and change in cognition over the 1-year follow-up was examined using hierarchical linear regression modeling for five cognitive domains (global cognition, language, memory, visuospatial abilities, and attention-executive-psychomotor). High CRP levels were associated with subtle declines in attention-executive-psychomotor performance (CRP beta=-0.22, P=.04) after adjusting for the effects of age and cognitive performance at study entry. CRP was not significantly associated with change in language, memory, or visuospatial performance. CONCLUSION: These data provide preliminary evidence that inflammation, potentially contributing to atherosclerotic processes, may underlie the association between high CRP and changes in attention-executive-psychomotor performance.
OBJECTIVES: To prospectively relate C-reactive protein (CRP), a systemic marker of inflammation, to cognitive change over a 1-year follow-up period. DESIGN: Prospective 1-year follow-up. SETTING:Outpatient university medical setting. PARTICIPANTS: Seventy-eight adults (aged 56-84; 39% female) with cardiovascular disease. MEASUREMENTS: CRP levels were measured using a high-sensitivity assay, and participants completed a neuropsychological battery at study entry. Neuropsychological assessment was repeated 1 year later. RESULTS: The association between CRP and change in cognition over the 1-year follow-up was examined using hierarchical linear regression modeling for five cognitive domains (global cognition, language, memory, visuospatial abilities, and attention-executive-psychomotor). High CRP levels were associated with subtle declines in attention-executive-psychomotor performance (CRP beta=-0.22, P=.04) after adjusting for the effects of age and cognitive performance at study entry. CRP was not significantly associated with change in language, memory, or visuospatial performance. CONCLUSION: These data provide preliminary evidence that inflammation, potentially contributing to atherosclerotic processes, may underlie the association between high CRP and changes in attention-executive-psychomotor performance.
Authors: Thomas A Pearson; George A Mensah; R Wayne Alexander; Jeffrey L Anderson; Richard O Cannon; Michael Criqui; Yazid Y Fadl; Stephen P Fortmann; Yuling Hong; Gary L Myers; Nader Rifai; Sidney C Smith; Kathryn Taubert; Russell P Tracy; Frank Vinicor Journal: Circulation Date: 2003-01-28 Impact factor: 29.690
Authors: J C Morris; A Heyman; R C Mohs; J P Hughes; G van Belle; G Fillenbaum; E D Mellits; C Clark Journal: Neurology Date: 1989-09 Impact factor: 9.910
Authors: Reinhold Schmidt; Helena Schmidt; J David Curb; Kamal Masaki; Lon R White; Lenore J Launer Journal: Ann Neurol Date: 2002-08 Impact factor: 10.422
Authors: Reijo S Tilvis; Mervi H Kähönen-Väre; Juha Jolkkonen; Jaakko Valvanne; Kaisu H Pitkala; Timo E Strandberg Journal: J Gerontol A Biol Sci Med Sci Date: 2004-03 Impact factor: 6.053
Authors: Sarah R Gillett; Evan L Thacker; Abraham J Letter; Leslie A McClure; Virginia G Wadley; Frederick W Unverzagt; Brett M Kissela; Richard E Kennedy; Stephen P Glasser; Deborah A Levine; Mary Cushman Journal: Clin Neuropsychol Date: 2015-05-15 Impact factor: 3.535
Authors: Jeremy M Silverman; James Schmeidler; Michal S Beeri; Clive Rosendorff; Mary Sano; Hillel T Grossman; José R Carrión-Baralt; Irina N Bespalova; Rebecca West; Vahram Haroutunian Journal: Neurology Date: 2012-08-15 Impact factor: 9.910
Authors: Patricia Katz; Laura Julian; Mary C Tonner; Jinoos Yazdany; Laura Trupin; Edward Yelin; Lindsey A Criswell Journal: Arthritis Care Res (Hoboken) Date: 2012-04 Impact factor: 4.794
Authors: Brianne Magouirk Bettcher; Reva Wilheim; Taylor Rigby; Ralph Green; Joshua W Miller; Caroline A Racine; Kristine Yaffe; Bruce L Miller; Joel H Kramer Journal: Brain Behav Immun Date: 2011-08-06 Impact factor: 7.217
Authors: Ozioma C Okonkwo; Ronald A Cohen; John Gunstad; Geoffrey Tremont; Michael L Alosco; Athena Poppas Journal: Cerebrovasc Dis Date: 2010-08-05 Impact factor: 2.762