OBJECTIVE: To prospectively investigate whether baseline findings on specific cardiovascular indices are predictive of subsequent rate of decline in Attention-Executive-Psychomotor function in a cohort of ambulatory older adults with cardiovascular diseases (CVDs). METHODS: One hundred seventy-two older adults with CVD were administered a neuropsychological battery of executive functions tests at study entry, and at 12 and 36 months thereafter. At study entry, they also underwent vascular assessments including cardiac output, ejection fraction, blood pressure (BP), brachial artery reactivity, and carotid intima media thickness. Random coefficient regressions were used to investigate the effect of these cardiac indices on rate of decline in Attention-Executive-Psychomotor function. RESULTS: Cardiac output, systolic BP variability, and diastolic BP variability predicted decline in Attention-Executive-Psychomotor function. Specifically, lower cardiac output, reduced variability in systolic BP, and increased variability in diastolic BP were associated with a faster rate of decline in Attention-Executive-Psychomotor function. Mean resting systolic and diastolic blood pressure did not predict decline in Attention-Executive-Psychomotor function. CONCLUSIONS: Decline in frontal-subcortical cognitive functions among patients with CVDs appears to be mediated by systemic hypoperfusion and variability in blood pressure. The precise nature of these relationships, especially with regard to blood pressure variability, is complex and demands continued investigation.
OBJECTIVE: To prospectively investigate whether baseline findings on specific cardiovascular indices are predictive of subsequent rate of decline in Attention-Executive-Psychomotor function in a cohort of ambulatory older adults with cardiovascular diseases (CVDs). METHODS: One hundred seventy-two older adults with CVD were administered a neuropsychological battery of executive functions tests at study entry, and at 12 and 36 months thereafter. At study entry, they also underwent vascular assessments including cardiac output, ejection fraction, blood pressure (BP), brachial artery reactivity, and carotid intima media thickness. Random coefficient regressions were used to investigate the effect of these cardiac indices on rate of decline in Attention-Executive-Psychomotor function. RESULTS:Cardiac output, systolic BP variability, and diastolic BP variability predicted decline in Attention-Executive-Psychomotor function. Specifically, lower cardiac output, reduced variability in systolic BP, and increased variability in diastolic BP were associated with a faster rate of decline in Attention-Executive-Psychomotor function. Mean resting systolic and diastolic blood pressure did not predict decline in Attention-Executive-Psychomotor function. CONCLUSIONS: Decline in frontal-subcortical cognitive functions among patients with CVDs appears to be mediated by systemic hypoperfusion and variability in blood pressure. The precise nature of these relationships, especially with regard to blood pressure variability, is complex and demands continued investigation.
Authors: Ronald A Cohen; Athena Poppas; Daniel E Forman; Karin F Hoth; Andreana P Haley; John Gunstad; Angela L Jefferson; David F Tate; Robert H Paul; Lawrence H Sweet; Mokato Ono; Beth A Jerskey; Marie Gerhard-Herman Journal: J Clin Exp Neuropsychol Date: 2008-06-16 Impact factor: 2.475
Authors: Rebecca F Gottesman; Maura A Grega; Maryanne M Bailey; Scott L Zeger; William A Baumgartner; Guy M McKhann; Ola A Selnes Journal: Behav Neurol Date: 2010 Impact factor: 3.342
Authors: M P J van Boxtel; L H G Henskens; A A Kroon; P A M Hofman; E H B M Gronenschild; J Jolles; P W de Leeuw Journal: J Hum Hypertens Date: 2006-01 Impact factor: 3.012
Authors: Ozioma C Okonkwo; Ronald A Cohen; John Gunstad; Geoffrey Tremont; Michael L Alosco; Athena Poppas Journal: Cerebrovasc Dis Date: 2010-08-05 Impact factor: 2.762
Authors: David F Tate; Angela L Jefferson; Adam M Brickman; Karin F Hoth; John Gunstad; Kathryn Bramley; Robert H Paul; Athena Poppas; Ronald A Cohen Journal: Brain Imaging Behav Date: 2008-09-01 Impact factor: 3.978
Authors: Lena L Law; Kate E Sprecher; Ryan J Dougherty; Dorothy F Edwards; Rebecca L Koscik; Catherine L Gallagher; Cynthia M Carlsson; Henrik Zetterberg; Kaj Blennow; Sanjay Asthana; Mark A Sager; Bruce P Hermann; Sterling C Johnson; Dane B Cook; Barbara B Bendlin; Ozioma C Okonkwo Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: Lena L Law; Stephanie A Schultz; Elizabeth A Boots; Jean A Einerson; Ryan J Dougherty; Jennifer M Oh; Claudia E Korcarz; Dorothy F Edwards; Rebecca L Koscik; N Maritza Dowling; Catherine L Gallagher; Barbara B Bendlin; Cynthia M Carlsson; Sanjay Asthana; Bruce P Hermann; Mark A Sager; Sterling C Johnson; Dane B Cook; James H Stein; Ozioma C Okonkwo Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Rianne A A de Heus; Christophe Tzourio; Emily Jo Lynn Lee; Melissa Opozda; Andrew D Vincent; Kaarin J Anstey; Albert Hofman; Kazuomi Kario; Simona Lattanzi; Lenore J Launer; Yuan Ma; Rajiv Mahajan; Simon P Mooijaart; Michiaki Nagai; Ruth Peters; Deborah Turnbull; Yuichiro Yano; Jurgen A H R Claassen; Phillip J Tully Journal: Hypertension Date: 2021-09-20 Impact factor: 9.897
Authors: Therese A Keary; Rachel Galioto; Joel Hughes; Donna Waechter; Mary Beth Spitznagel; James Rosneck; Richard Josephson; John Gunstad Journal: Cardiovasc Psychiatry Neurol Date: 2012-09-04
Authors: Stephen P Juraschek; Natalie Daya; Lawrence J Appel; Edgar R Miller; Kunihiro Matsushita; Erin D Michos; B Gwen Windham; Christie M Ballantyne; Elizabeth Selvin Journal: J Am Geriatr Soc Date: 2019-07-10 Impact factor: 7.538
Authors: Lin Cao; Sean D Pokorney; Kathleen Hayden; Kathleen Welsh-Bohmer; L Kristin Newby Journal: J Am Heart Assoc Date: 2015-08-03 Impact factor: 5.501