Literature DB >> 18770604

Isolation and analysis of Mycobacterium tuberculosis mycolic acids.

Catherine Vilchèze1, William R Jacobs.   

Abstract

Mycolic acids are an important constituent of the mycobacterial cell wall. Changes in the structure or composition of mycolic acids have been associated with modification of cell wall permeability and attenuation of pathogenic Mycobacterium tuberculosis strains. This unit describes the isolation of M. tuberculosis mycolic acids and their analysis by either thin-layer chromatography or high-performance liquid chromatography. Both techniques have been extensively used to study (1) mycolic acid biosynthesis, (2) the role of mycolic acids in mycobacterial virulence, (3) the effect of antituberculosis drugs targeting the cell wall, and (4) taxonomic purposes.

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Year:  2007        PMID： 18770604     DOI： 10.1002/9780471729259.mc10a03s05

Source DB:  PubMed          Journal:  Curr Protoc Microbiol


  9 in total

1.  Keto-mycolic acid-dependent pellicle formation confers tolerance to drug-sensitive Mycobacterium tuberculosis.

Authors:  Dhinakaran Sambandan; Dee N Dao; Brian C Weinrick; Catherine Vilchèze; Sudagar S Gurcha; Anil Ojha; Laurent Kremer; Gurdyal S Besra; Graham F Hatfull; William R Jacobs
Journal:  mBio       Date:  2013-05-07       Impact factor: 7.867

2.  Secretory phosphatases deficient mutant of Mycobacterium tuberculosis imparts protection at the primary site of infection in guinea pigs.

Authors:  Priyanka Chauhan; P Vineel Reddy; Ramandeep Singh; Neetika Jaisinghani; Sheetal Gandotra; Anil K Tyagi
Journal:  PLoS One       Date:  2013-10-18       Impact factor: 3.240

3.  Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

Authors:  Rafael Prados-Rosales; Leandro Carreño; Tingting Cheng; Caroline Blanc; Brian Weinrick; Adel Malek; Todd L Lowary; Andres Baena; Maju Joe; Yu Bai; Rainer Kalscheuer; Ana Batista-Gonzalez; Noemi A Saavedra; Leticia Sampedro; Julen Tomás; Juan Anguita; Shang-Cheng Hung; Ashish Tripathi; Jiayong Xu; Aharona Glatman-Freedman; Williams R Jacobs; John Chan; Steven A Porcelli; Jacqueline M Achkar; Arturo Casadevall
Journal:  PLoS Pathog       Date:  2017-03-09       Impact factor: 6.823

4.  Phospholipid homeostasis, membrane tenacity and survival of Mtb in lipid rich conditions is determined by MmpL11 function.

Authors:  Ankur Bothra; Prabhakar Arumugam; Vipul Panchal; Dilip Menon; Sonali Srivastava; Deepthi Shankaran; Ananya Nandy; Neetika Jaisinghani; Archana Singh; Rajesh S Gokhale; Sheetal Gandotra; Vivek Rao
Journal:  Sci Rep       Date:  2018-05-29       Impact factor: 4.379

5.  Amycolatopsis camponoti sp. nov., new tetracenomycin-producing actinomycete isolated from carpenter ant Camponotus vagus.

Authors:  Yuliya V Zakalyukina; Ilya A Osterman; Jacqueline Wolf; Meina Neumann-Schaal; Imen Nouioui; Mikhail V Biryukov
Journal:  Antonie Van Leeuwenhoek       Date:  2022-02-26       Impact factor: 2.158

6.  Elucidating the Antimycobacterial Mechanism of Action of Ciprofloxacin Using Metabolomics.

Authors:  Kirsten E Knoll; Zander Lindeque; Adetomiwa A Adeniji; Carel B Oosthuizen; Namrita Lall; Du Toit Loots
Journal:  Microorganisms       Date:  2021-05-28

7.  Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction.

Authors:  Catherine Vilchèze; Travis Hartman; Brian Weinrick; William R Jacobs
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

8.  Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.

Authors:  Catherine Vilchèze; Yossef Av-Gay; Rodgoun Attarian; Zhen Liu; Manzour H Hazbón; Roberto Colangeli; Bing Chen; Weijun Liu; David Alland; James C Sacchettini; William R Jacobs
Journal:  Mol Microbiol       Date:  2008-07-21       Impact factor: 3.501

9.  The mycolic acid reductase Rv2509 has distinct structural motifs and is essential for growth in slow-growing mycobacteria.

Authors:  Asma Javid; Charlotte Cooper; Albel Singh; Steffen Schindler; Milena Hänisch; Robert L Marshall; Rainer Kalscheuer; Vassiliy N Bavro; Apoorva Bhatt
Journal:  Mol Microbiol       Date:  2019-12-17       Impact factor: 3.501
  9 in total

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