Literature DB >> 18769056

Caveolin and proteasome in tocotrienol mediated myocardial protection.

Manika Das1, Samarjit Das, Ping Wang, Saul R Powell, Dipak K Das.   

Abstract

The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result of myocardial apoptosis. To study the mechanism of tocotrienol mediated cardioprotection, we examined the interaction and/or translocation of different signaling components to caveolins and activity of proteasome. The results suggest that differential interaction of MAP kinases with caveolin 1/3 in conjuncture with proteasome stabilization play a unique role in tocotrienol mediated cardioprotection possibly by altering the availability of pro-survival and anti-survival proteins. Copyright 2008 S. Karger AG, Basel.

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Year:  2008        PMID： 18769056      PMCID： PMC2929803          DOI： 10.1159/000149807

Source DB:  PubMed          Journal:  Cell Physiol Biochem        ISSN： 1015-8987


  32 in total

1.  Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains.

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Journal:  J Biol Chem       Date:  1996-04-19       Impact factor: 5.157

2.  Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee).

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Journal:  Am J Clin Nutr       Date:  1991-04       Impact factor: 7.045

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Authors:  A A Qureshi; N Qureshi; J O Hasler-Rapacz; F E Weber; V Chaudhary; T D Crenshaw; A Gapor; A S Ong; Y H Chong; D Peterson
Journal:  Am J Clin Nutr       Date:  1991-04       Impact factor: 7.045

4.  Ischemic preconditioning reduces apoptosis by upregulating anti-death gene Bcl-2.

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Journal:  Circulation       Date:  1999-11-09       Impact factor: 29.690

5.  Src tyrosine kinase is the trigger but not the mediator of ischemic preconditioning.

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Journal:  Am J Physiol Heart Circ Physiol       Date:  2001-09       Impact factor: 4.733

Review 6.  Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis.

Authors:  Suparna Mazumder; Dragos Plesca; Alexandru Almasan
Journal:  Methods Mol Biol       Date:  2008

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Journal:  Eur J Biochem       Date:  1996-06-01

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Journal:  FASEB J       Date:  2003-09-04       Impact factor: 5.191

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Journal:  Mol Cell Biol       Date:  1994-01       Impact factor: 4.272

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Journal:  Cancer Res       Date:  1987-01-01       Impact factor: 12.701
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  16 in total

Review 1.  The ubiquitin-proteasome system in myocardial ischaemia and preconditioning.

Authors:  Saul R Powell; Andras Divald
Journal:  Cardiovasc Res       Date:  2009-09-30       Impact factor: 10.787

2.  Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation.

Authors:  Hannah R Vasanthi; R P Parameswari; Dipak K Das
Journal:  Genes Nutr       Date:  2011-05-21       Impact factor: 5.523

3.  Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells.

Authors:  Dorrelyn Patacsil; Anh Thu Tran; Youn Sook Cho; Simeng Suy; Francisco Saenz; Irina Malyukova; Habtom Ressom; Sean P Collins; Robert Clarke; Deepak Kumar
Journal:  J Nutr Biochem       Date:  2011-03-22       Impact factor: 6.048

4.  Why tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E.

Authors:  Valentina Viola; Francesca Pilolli; Marta Piroddi; Elisa Pierpaoli; Fiorenza Orlando; Mauro Provinciali; Michele Betti; Francesco Mazzini; Francesco Galli
Journal:  Genes Nutr       Date:  2011-04-20       Impact factor: 5.523

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Authors:  Bharat B Aggarwal; Chitra Sundaram; Seema Prasad; Ramaswamy Kannappan
Journal:  Biochem Pharmacol       Date:  2010-08-07       Impact factor: 5.858

Review 6.  The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants.

Authors:  Zuzana Majkova; Michal Toborek; Bernhard Hennig
Journal:  J Cell Mol Med       Date:  2010-10       Impact factor: 5.310

7.  Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine diet.

Authors:  Ku-Zaifah Norsidah; Ahmad Yusof Asmadi; Ayob Azizi; Othman Faizah; Yusof Kamisah
Journal:  J Physiol Biochem       Date:  2012-12-04       Impact factor: 4.158

Review 8.  Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence.

Authors:  Sok Kuan Wong; Yusof Kamisah; Norazlina Mohamed; Norliza Muhammad; Norliana Masbah; Nur Azlina Mohd Fahami; Isa Naina Mohamed; Ahmad Nazun Shuid; Qodriyah Mohd Saad; Azman Abdullah; Nur-Vaizura Mohamad; Nurul' Izzah Ibrahim; Kok-Lun Pang; Yoke Yue Chow; Benjamin Ka Seng Thong; Shaanthana Subramaniam; Chin Yi Chan; Soelaiman Ima-Nirwana; And Kok-Yong Chin
Journal:  Nutrients       Date:  2020-01-19       Impact factor: 5.717

9.  Caveolin as a potential drug target for cardiovascular protection.

Authors:  Stephanie L Sellers; Andy E Trane; Pascal N Bernatchez
Journal:  Front Physiol       Date:  2012-07-18       Impact factor: 4.566

10.  Inhibitory effects of palm tocotrienol-rich fraction supplementation on bilirubin-metabolizing enzymes in hyperbilirubinemic adult rats.

Authors:  Yusof Kamisah; Jing Jye Lim; Chew-Lian Lim; Ahmad Y Asmadi
Journal:  PLoS One       Date:  2014-02-20       Impact factor: 3.240
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