Literature DB >> 18763827

HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis.

Heidi R Bokesch1, Antony Wamiru, Stuart F J Le Grice, John A Beutler, Tawnya C McKee, James B McMahon.   

Abstract

Three new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of NMR and MS data. Compounds 1-3 inhibited HIV-1 RNase H in vitro with IC50 values of 1.46, >18, and 1.19 microM, respectively. However, in a XTT-based cell viability assay using the human T-cell line CEM-SS infected with HIV-1 RT, none of the compounds inhibited the cytopathic effect of HIV-1 infection at the highest dose tested (20 microg/mL).

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Year:  2008        PMID： 18763827      PMCID： PMC2586124          DOI： 10.1021/np8002518

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

1.  Isolation and antioxidant activity of galloyl flavonol glycosides from the seashore plant, Pemphis acidula.

Authors:  T Masuda; K Iritani; S Yonemori; Y Oyama; Y Takeda
Journal:  Biosci Biotechnol Biochem       Date:  2001-06       Impact factor: 2.043

2.  An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis.

Authors:  Kentaro Takada; Alun Bermingham; Barry R O'Keefe; Antony Wamiru; John A Beutler; Stuart F J Le Grice; John Lloyd; Kirk R Gustafson; James B McMahon
Journal:  J Nat Prod       Date:  2007-10-13       Impact factor: 4.050

3.  A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.

Authors:  Nguyen Tien Dat; KiHwan Bae; Antony Wamiru; James B McMahon; Stuart F J Le Grice; Marion Bona; John A Beutler; Young Ho Kim
Journal:  J Nat Prod       Date:  2007-03-31       Impact factor: 4.050

4.  A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts.

Authors:  J H Cardellina; M H Munro; R W Fuller; K P Manfredi; T C McKee; M Tischler; H R Bokesch; K R Gustafson; J A Beutler; M R Boyd
Journal:  J Nat Prod       Date:  1993-07       Impact factor: 4.050

5.  Antioxidant galloylated flavonol glycosides from Calliandra haematocephala.

Authors:  F A Moharram; M S A Marzouk; M T Ibrahim; T J Mabry
Journal:  Nat Prod Res       Date:  2006-08       Impact factor: 2.861

6.  A semiautomated multiparameter approach for anti-HIV drug screening.

Authors:  R J Gulakowski; J B McMahon; P G Staley; R A Moran; M R Boyd
Journal:  J Virol Methods       Date:  1991-06       Impact factor: 2.014

7.  Siamenol, a new carbazole alkaloid from Murraya siamensis.

Authors:  K M Meragelman; T C McKee; M R Boyd
Journal:  J Nat Prod       Date:  2000-03       Impact factor: 4.050

8.  Anti-oxidant constituents from Sedum takesimense.

Authors:  Phuong Thien Thuong; Ho Jeong Kang; MinKyun Na; WenYi Jin; Ui Jung Youn; Yeon Hee Seong; Kyung-Sik Song; Byung-Sun Min; KiHwan Bae
Journal:  Phytochemistry       Date:  2007-07-20       Impact factor: 4.072

9.  A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity.

Authors:  Michael A Parniak; Kyung-Lyum Min; Scott R Budihas; Stuart F J Le Grice; John A Beutler
Journal:  Anal Biochem       Date:  2003-11-01       Impact factor: 3.365
  9 in total
  9 in total

1.  Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H.

Authors:  Zhaoyong Xi; Zhengqiang Wang; Stefan G Sarafianos; Nataliya S Myshakina; Rieko Ishima
Journal:  ACS Infect Dis       Date:  2019-10-02       Impact factor: 5.084

2.  Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.

Authors:  Suhman Chung; Michaela Wendeler; Jason W Rausch; Greg Beilhartz; Matthias Gotte; Barry R O'Keefe; Alun Bermingham; John A Beutler; Shixin Liu; Xiaowei Zhuang; Stuart F J Le Grice
Journal:  Antimicrob Agents Chemother       Date:  2010-06-14       Impact factor: 5.191

3.  Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.

Authors:  Eric B Lansdon; Qi Liu; Stephanie A Leavitt; Mini Balakrishnan; Jason K Perry; Candra Lancaster-Moyer; Nilima Kutty; Xiaohong Liu; Neil H Squires; William J Watkins; Thorsten A Kirschberg
Journal:  Antimicrob Agents Chemother       Date:  2011-04-04       Impact factor: 5.191

4.  Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.

Authors:  Karen A Kirby; Bruno Marchand; Yee Tsuey Ong; Tanyaradzwa P Ndongwe; Atsuko Hachiya; Eleftherios Michailidis; Maxwell D Leslie; Daniel V Sietsema; Tracy L Fetterly; Christopher A Dorst; Kamalendra Singh; Zhengqiang Wang; Michael A Parniak; Stefan G Sarafianos
Journal:  Antimicrob Agents Chemother       Date:  2012-01-17       Impact factor: 5.191

5.  Magnetic Ligand Fishing as a Targeting Tool for HPLC-HRMS-SPE-NMR: α-Glucosidase Inhibitory Ligands and Alkylresorcinol Glycosides from Eugenia catharinae.

Authors:  Sileshi G Wubshet; Inês M C Brighente; Ruin Moaddel; Dan Staerk
Journal:  J Nat Prod       Date:  2015-10-23       Impact factor: 4.050

Review 6.  Comparison of analytical techniques for the identification of bioactive compounds from natural products.

Authors:  Łukasz Cieśla; Ruin Moaddel
Journal:  Nat Prod Rep       Date:  2016-07-01       Impact factor: 13.423

Review 7.  Large Multidomain Protein NMR: HIV-1 Reverse Transcriptase Precursor in Solution.

Authors:  Tatiana V Ilina; Zhaoyong Xi; Teresa Brosenitsch; Nicolas Sluis-Cremer; Rieko Ishima
Journal:  Int J Mol Sci       Date:  2020-12-15       Impact factor: 5.923

8.  The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.

Authors:  John E Tavis; Xiaohong Cheng; Yuan Hu; Michael Totten; Feng Cao; Eleftherios Michailidis; Rajeev Aurora; Marvin J Meyers; E Jon Jacobsen; Michael A Parniak; Stefan G Sarafianos
Journal:  PLoS Pathog       Date:  2013-01-22       Impact factor: 6.823

Review 9.  Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.

Authors:  Bahare Salehi; Nanjangud V Anil Kumar; Bilge Şener; Mehdi Sharifi-Rad; Mehtap Kılıç; Gail B Mahady; Sanja Vlaisavljevic; Marcello Iriti; Farzad Kobarfard; William N Setzer; Seyed Abdulmajid Ayatollahi; Athar Ata; Javad Sharifi-Rad
Journal:  Int J Mol Sci       Date:  2018-05-14       Impact factor: 5.923
  9 in total

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