Literature DB >> 17397219

A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.

Nguyen Tien Dat1, KiHwan Bae, Antony Wamiru, James B McMahon, Stuart F J Le Grice, Marion Bona, John A Beutler, Young Ho Kim.   

Abstract

A new dimeric lactone, ardimerin digallate (1), was isolated from the whole plants of Ardisia japonica, along with six known constituents. The structure of 1 was established on the basis of spectroscopic analysis including 1D- and 2D-NMR techniques. Compound 1 inhibited HIV-1 and HIV-2 RNase H in vitro with IC50 values of 1.5 and 1.1 microM, respectively.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17397219     DOI： 10.1021/np060359m

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

1.  Expression of an Mg2+-dependent HIV-1 RNase H construct for drug screening.

Authors:  Richard V Farias; Deborah A Vargas; Andres E Castillo; Beatriz Valenzuela; Marie L Coté; Monica J Roth; Oscar Leon
Journal:  Antimicrob Agents Chemother       Date:  2011-07-18       Impact factor: 5.191

2.  Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

Authors:  Suhman Chung; Daniel M Himmel; Jian-Kang Jiang; Krzysztof Wojtak; Joseph D Bauman; Jason W Rausch; Jennifer A Wilson; John A Beutler; Craig J Thomas; Eddy Arnold; Stuart F J Le Grice
Journal:  J Med Chem       Date:  2011-06-02       Impact factor: 7.446

3.  Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.

Authors:  Suhman Chung; Michaela Wendeler; Jason W Rausch; Greg Beilhartz; Matthias Gotte; Barry R O'Keefe; Alun Bermingham; John A Beutler; Shixin Liu; Xiaowei Zhuang; Stuart F J Le Grice
Journal:  Antimicrob Agents Chemother       Date:  2010-06-14       Impact factor: 5.191

4.  Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.

Authors:  Eric B Lansdon; Qi Liu; Stephanie A Leavitt; Mini Balakrishnan; Jason K Perry; Candra Lancaster-Moyer; Nilima Kutty; Xiaohong Liu; Neil H Squires; William J Watkins; Thorsten A Kirschberg
Journal:  Antimicrob Agents Chemother       Date:  2011-04-04       Impact factor: 5.191

5.  Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.

Authors:  Karen A Kirby; Bruno Marchand; Yee Tsuey Ong; Tanyaradzwa P Ndongwe; Atsuko Hachiya; Eleftherios Michailidis; Maxwell D Leslie; Daniel V Sietsema; Tracy L Fetterly; Christopher A Dorst; Kamalendra Singh; Zhengqiang Wang; Michael A Parniak; Stefan G Sarafianos
Journal:  Antimicrob Agents Chemother       Date:  2012-01-17       Impact factor: 5.191

6.  Systematic characterization of the effective constituents and molecular mechanisms of Ardisiae Japonicae Herba using UPLC-Orbitrap Fusion MS and network pharmacology.

Authors:  Suxiang Feng; Jie Yuan; Di Zhao; Rongrong Li; Xuefang Liu; Yange Tian; Jiansheng Li
Journal:  PLoS One       Date:  2022-06-15       Impact factor: 3.752

7.  HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis.

Authors:  Heidi R Bokesch; Antony Wamiru; Stuart F J Le Grice; John A Beutler; Tawnya C McKee; James B McMahon
Journal:  J Nat Prod       Date:  2008-09-03       Impact factor: 4.050

8.  Synthesis and anti-cancer activity of a glycosyl library of N-acetylglucosamine-bearing oleanolic acid.

Authors:  Yi-Bing Zeng; Hsin-Min Hsiao; She-Hung Chan; Ying-Hsin Wang; You-Yu Lin; Yu-Hsuan Kuo; Jih-Hwa Guh; Pi-Hui Liang
Journal:  Mol Divers       Date:  2013-09-25       Impact factor: 2.943

9.  Synthesis of 3,3'-di-O-methyl ardimerin and exploration of its DNA binding properties.

Authors:  Miran Mavlan; Kevin Ng; Harmanpreet Panesar; Akop Yepremyan; Thomas G Minehan
Journal:  Org Lett       Date:  2014-04-09       Impact factor: 6.005

10.  Simultaneous Quantification of Gallic Acid, Bergenin, Epicatechin, Epicatechin Gallate, Isoquercitrin, and Quercetin-3-Rhamnoside in Rat Plasma by LC-MS/MS Method and Its Application to Pharmacokinetics after Oral Administration of Ardisia japonica Extract.

Authors:  Xie-An Yu; John Teye Azietaku; Jin Li; Hui Wang; Fang Zheng; Jia Hao; Yan-Xu Chang
Journal:  Evid Based Complement Alternat Med       Date:  2018-01-14       Impact factor: 2.629
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.