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Literature DB >> 18763762

Selecting aptamers for a glycoprotein through the incorporation of the boronic acid moiety.

Minyong Li¹, Na Lin, Zhen Huang, Lupei Du, Craig Altier, Hao Fang, Binghe Wang.

Abstract

The first general method for the selection of boronic acid-based aptamers (boronolectins) that allows for glycan substructure focusing is described. Using fibrinogen as a model glycoprotein, we have selected boronic acid-modified DNA aptamers that have high affinities (low nM Kd) and the ability to recognize changes in the glycosylation site. The method developed should also be applicable to the development of aptamers for other glycoproducts, such as glycolipids and glycopeptides.

Entities: Chemical Species

Mesh：

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Year: 2008 PMID： 18763762 PMCID： PMC2655352 DOI： 10.1021/ja801510d

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

12 in total

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34 in total

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