Literature DB >> 18762017

PI3K enters beta-testing.

Adam J Shaywitz1, Kevin D Courtney, Akash Patnaik, Lewis C Cantley.   

Abstract

Phosphoinositide-3-OH kinases (PI3K) are critical regulators of cell metabolism, growth, and survival. In a recent publication in Nature, Jia et al. (2008) identify specific functions of the p110beta isoform of PI3K in glucose metabolism, cellular proliferation, and tumorigenesis.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18762017      PMCID： PMC3389549          DOI： 10.1016/j.cmet.2008.08.011

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  12 in total

1.  Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase.

Authors:  Lei Bi; Ichiro Okabe; David J Bernard; Robert L Nussbaum
Journal:  Mamm Genome       Date:  2002-03       Impact factor: 2.957

Review 2.  The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.

Authors:  Jeffrey A Engelman; Ji Luo; Lewis C Cantley
Journal:  Nat Rev Genet       Date:  2006-08       Impact factor: 53.242

3.  Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.

Authors:  Lazaros C Foukas; Marc Claret; Wayne Pearce; Klaus Okkenhaug; Stephen Meek; Emma Peskett; Sara Sancho; Andrew J H Smith; Dominic J Withers; Bart Vanhaesebroeck
Journal:  Nature       Date:  2006-04-12       Impact factor: 49.962

4.  Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase.

Authors:  Sohye Kang; Adam Denley; Bart Vanhaesebroeck; Peter K Vogt
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-23       Impact factor: 11.205

5.  Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.

Authors:  Saskia M Brachmann; Kohjiro Ueki; Jeffrey A Engelman; Ronald C Kahn; Lewis C Cantley
Journal:  Mol Cell Biol       Date:  2005-03       Impact factor: 4.272

6.  Activation of PI 3-kinase by G protein betagamma subunits.

Authors:  O Hazeki; T Okada; H Kurosu; S Takasuga; T Suzuki; T Katada
Journal:  Life Sci       Date:  1998       Impact factor: 5.037

7.  FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression.

Authors:  Wenwei Zhang; Sandip Patil; Balwant Chauhan; Shaodong Guo; David R Powell; Jamie Le; Angelos Klotsas; Ryan Matika; Xiangshan Xiao; Roberta Franks; Kim A Heidenreich; Mini P Sajan; Robert V Farese; Donna Beer Stolz; Patrick Tso; Seung-Hoi Koo; Marc Montminy; Terry G Unterman
Journal:  J Biol Chem       Date:  2006-02-21       Impact factor: 5.157

8.  Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.

Authors:  Shidong Jia; Zhenning Liu; Sen Zhang; Pixu Liu; Lei Zhang; Sang Hyun Lee; Jing Zhang; Sabina Signoretti; Massimo Loda; Thomas M Roberts; Jean J Zhao
Journal:  Nature       Date:  2008-06-25       Impact factor: 49.962

9.  The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

Authors:  Julie Guillermet-Guibert; Katja Bjorklof; Ashreena Salpekar; Cristiano Gonella; Faruk Ramadani; Antonio Bilancio; Stephen Meek; Andrew J H Smith; Klaus Okkenhaug; Bart Vanhaesebroeck
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-10       Impact factor: 11.205

10.  An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway.

Authors:  Hye-Won Shin; Mitsuko Hayashi; Savvas Christoforidis; Sandra Lacas-Gervais; Sebastian Hoepfner; Markus R Wenk; Jan Modregger; Sandrine Uttenweiler-Joseph; Matthias Wilm; Arne Nystuen; Wayne N Frankel; Michele Solimena; Pietro De Camilli; Marino Zerial
Journal:  J Cell Biol       Date:  2005-08-15       Impact factor: 10.539
View more
  4 in total

1.  Development of a peptide-drug conjugate for prostate cancer therapy.

Authors:  Wanyi Tai; Ravi S Shukla; Bin Qin; Benyi Li; Kun Cheng
Journal:  Mol Pharm       Date:  2011-05-03       Impact factor: 4.939

Review 2.  Development of phosphoinositide-3 kinase pathway inhibitors for advanced cancer.

Authors:  James M Cleary; Geoffrey I Shapiro
Journal:  Curr Oncol Rep       Date:  2010-03       Impact factor: 5.075

3.  Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα).

Authors:  Yang Li; Lina He; Ni Zeng; Divya Sahu; Enrique Cadenas; Colin Shearn; Wei Li; Bangyan L Stiles
Journal:  J Biol Chem       Date:  2013-07-08       Impact factor: 5.157

4.  Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.

Authors:  Hind Al-Qassab; Mark A Smith; Elaine E Irvine; Julie Guillermet-Guibert; Marc Claret; Agharul I Choudhury; Colin Selman; Kaisa Piipari; Melanie Clements; Steven Lingard; Keval Chandarana; Jimmy D Bell; Gregory S Barsh; Andrew J H Smith; Rachel L Batterham; Michael L J Ashford; Bart Vanhaesebroeck; Dominic J Withers
Journal:  Cell Metab       Date:  2009-11       Impact factor: 27.287
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.