Literature DB >> 18761442

Fluorescence and hybridization properties of peptide nucleic acid containing a substituted phenylpyrrolocytosine designed to engage Guanine with an additional H-bond.

Filip Wojciechowski1, Robert H E Hudson.   

Abstract

A new pyrrolocytosine derivative has been designed to selectively interact with guanine and has been evaluated in peptide nucleic acid where it imparts increased selective binding affinity for complementary oligonucleotides. The modified nucleobase also possesses an exceptionally high fluorescence quantum yield that is responsive to hybridization.

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Year:  2008        PMID： 18761442     DOI： 10.1021/ja804233g

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  18 in total

1.  Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer.

Authors:  Henrik Gustmann; Anna-Lena J Segler; Dnyaneshwar B Gophane; Andreas J Reuss; Christian Grünewald; Markus Braun; Julia E Weigand; Snorri Th Sigurdsson; Josef Wachtveitl
Journal:  Nucleic Acids Res       Date:  2019-01-10       Impact factor: 16.971

Review 2.  Fluorescent nucleobases as tools for studying DNA and RNA.

Authors:  Wang Xu; Ke Min Chan; Eric T Kool
Journal:  Nat Chem       Date:  2017-10-16       Impact factor: 24.427

3.  Synthesis and spectral characterization of environmentally responsive fluorescent deoxycytidine analogs.

Authors:  Adam A H Elmehriki; Mojmír Suchý; Kirby J Chicas; Filip Wojciechowski; Robert H E Hudson
Journal:  Artif DNA PNA XNA       Date:  2014

4.  Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine.

Authors:  Jiaxin Hu; David W Dodd; Robert H E Hudson; David R Corey
Journal:  Bioorg Med Chem Lett       Date:  2009-09-06       Impact factor: 2.823

5.  High density labeling of polymerase chain reaction products with the fluorescent base analogue tCo.

Authors:  Gudrun Stengel; Milan Urban; Byron W Purse; Robert D Kuchta
Journal:  Anal Chem       Date:  2009-11-01       Impact factor: 6.986

6.  An emissive C analog distinguishes between G, 8-oxoG, and T.

Authors:  Nicholas J Greco; Renatus W Sinkeldam; Yitzhak Tor
Journal:  Org Lett       Date:  2009-03-05       Impact factor: 6.005

7.  Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA.

Authors:  Rebecca Guza; Delshanee Kotandeniya; Kristopher Murphy; Thakshila Dissanayake; Chen Lin; George Madalin Giambasu; Rahul R Lad; Filip Wojciechowski; Shantu Amin; Shana J Sturla; Robert H E Hudson; Darrin M York; Ryszard Jankowiak; Roger Jones; Natalia Y Tretyakova
Journal:  Nucleic Acids Res       Date:  2011-01-17       Impact factor: 16.971

8.  Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs.

Authors:  Adrian G Torres; Martin M Fabani; Elena Vigorito; Donna Williams; Naowras Al-Obaidi; Filip Wojciechowski; Robert H E Hudson; Oliver Seitz; Michael J Gait
Journal:  Nucleic Acids Res       Date:  2011-11-08       Impact factor: 16.971

9.  A single-label phenylpyrrolocytidine provides a molecular beacon-like response reporting HIV-1 RT RNase H activity.

Authors:  Alexander S Wahba; Abbasali Esmaeili; Masad J Damha; Robert H E Hudson
Journal:  Nucleic Acids Res       Date:  2009-11-20       Impact factor: 16.971

10.  6-phenylpyrrolocytosine as a fluorescent probe to examine nucleotide flipping catalyzed by a DNA repair protein.

Authors:  Delshanee Kotandeniya; Melanie S Rogers; Jenna Fernandez; Sreenivas Kanugula; Robert H E Hudson; Freddys Rodriguez; John D Lipscomb; Natalia Tretyakova
Journal:  Biopolymers       Date:  2020-10-24       Impact factor: 2.505
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